Publications by authors named "Yutong Ji"

Background: The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with toxicities are frequently used to treat cancer. The current study addresses these challenges.

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Recent pan-cancer analysis revealed the global pattern and potential aetiologies of copy number variation signatures in human cancers, particularly those derived from non-hematopoietic tissues. In sharp contrast, the generally low CNV burden in leukemia leaves the CNV landscape and variations largely unexplored, impeding understanding of CNV in leukemia development. Through a comprehensive compilation of public datasets, we constructed LeukAtlas ( https://ngdc.

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Unnatural chemically modified nucleotide sugars UDP-4-SH-GalNAc was synthesized for the first time from a previously reported Benzyl 2-Amino-glucoypranoside derivative, with a total yield of 18.6%. UDP-4-SH-GalNAc was smaller in size than UDP-GalNAc calculated by Multiwfn, and its binding capability with glycosyltransferase was stronger than that of UDP-GalNAc and glycosyltransferase, which means the unnatural nucleotide sugars is equally well recognized by the enzyme and doped into the sugar chains.

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Non-alcoholic fatty liver disease (NAFLD) and myocardial infarction (MI) are two major health burdens with significant prevalence and mortality. This study aimed to explore the co-expressed genes to understand the relationship between NAFLD and MI and identify potential crucial biomarkers of NAFLD-related MI using bioinformatics and machine learning. Functional enrichment analysis was conducted, a co-protein-protein interaction (PPI) network diagram was constructed, and support vector machine-recursive feature elimination (SVM-RFE) and least absolute shrinkage and selection operator (LASSO) techniques were employed to identify one differentially expressed gene (DEG), Thrombospondin 1 (THBS1).

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Introduction: Osteoporosis and osteopenia, together known as low bone mineral density (LBMD), are common problems in the elderly. LBMD may cause fragility fractures in the elderly. The relationship between Vitamin E and LBMD in old Americans is still unclear.

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  • Mulberry bacterial wilt disease, caused by Ralstonia pseudosolanacearum, significantly impacts the silk-mulberry industry, especially affecting resistant (K10) and susceptible (G12) cultivars.
  • Through high-throughput sequencing, researchers identified Bacillus as a key beneficial bacteria in the resistant cultivar K10, then screened twelve Bacillus spp. isolates for their ability to combat the disease.
  • The isolate B. velezensis K0T24 showed strong antagonism towards R. pseudosolanacearum, inhibiting its growth by 82.47% and enhancing defenses in mulberry seedlings, ultimately providing over 55% control against the disease.
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Experimental studies have demonstrated that the gas phase contact angle (CA) of a surface nanobubble (SNB) is much smaller than that of a macroscopic gas bubble. This reduced CA plays a crucial role in prolonging the lifetime of SNBs by lowering the bubble pressure and preventing gas molecules from dissolving in the surrounding liquids. Despite extensive efforts to explain the anomalously small CA, a consensus about the underlying reasons is yet to be reached.

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  • Soil-borne diseases and pests significantly harm crop quality, yield, and farmer income, but can be controlled with allyl isothiocyanate (AITC), which is unstable and unevenly distributed in soil.
  • Researchers encapsulated AITC in modified diatomite granules, achieving a 27.6% loading that improved its stability and effectiveness against soil pathogens, leading to enhanced tomato growth and yield.
  • The encapsulated AITC effectively controlled soil pests for up to 7 months and increased tomato yield by 108%, highlighting this method as a beneficial approach for sustainable pest management.
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  • * The study tested various soil fumigants: dazomet, metham sodium, allyl isothiocyanate, chloropicrin, and dimethyl disulfide, finding chloropicrin (PIC) and metham sodium (MS) to be the most effective at controlling A. flavus.
  • * Peanuts grown in fumigated soil showed no detectable levels of aflatoxin B1 after storage, indicating that soil fumigation could greatly improve peanut safety for consumers, with plans for further research to explore commercial applications.
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Cancer-associated fibroblasts (CAFs), as important components of the tumor microenvironment, can regulate intercellular communication and tumor development by secreting extracellular vesicles (EVs). However, the role of CAF-derived EVs in ovarian cancer has not been fully elucidated. Here, using an EV-microRNA sequencing analysis, we reveal specific overexpression of microRNA (miR)-296-3p in activated CAF-derived EVs, which can be transferred to tumor cells to regulate the malignant phenotypes of ovarian cancer cells.

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  • Allyl isothiocyanate (AITC) is a biofumigant used to control soil pests that affect crop growth, and its effectiveness is influenced by soil moisture content and application methods.
  • Injection of AITC at 50 g/m showed limited diffusion in varying soil moisture conditions, while drip irrigation at 7.5 g/m allowed for greater lateral and vertical spread, effectively targeting soil-borne pathogens and weeds.
  • The study concluded that drip irrigation of AITC provides better pest control compared to injection methods, offering valuable insights for optimizing its application in agricultural practices.
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Background: Aparapotamon, a freshwater crab genus endemic to China, includes 13 species. The distribution of Aparapotamon spans the first and second tiers of China's terrain ladder, showing great altitudinal differences. To study the molecular mechanisms of adaptive evolution in Aparapotamon, we performed evolutionary analyses, including morphological, geographical, and phylogenetic analyses and divergence time estimation.

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Trapped nanobubbles are observed nucleating at nanopits on a pitted substrate, while surface nanobubbles are usually formed on the smooth solid surface in water. In this work, trapped nanobubbles and surface nanobubbles were captured by a tapping-mode atomic force microscope (AFM) on a nanopitted substrate based on the temperature difference method. A single trapped nanobubble was manipulated to change into a surface nanobubble, then to change into the trapped nanobubble again.

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The simulation and analysis of the degradation process of organic nitrogen contaminants in wastewater treatment facility effluent is important to the estimation of its actual contribution to eutrophication, and it is crucial to the developing of watershed protection plan. In this study, algal and algal/bacterial based bioassay was conducted to study the bioavailability of dissolved organic nitrogen contaminants in wastewater treatment plants effluents, and 4 kinetic models were used to describe the mineralization process. The traditional 1-pool model that was commonly used in water quality models showed poor correlation (r = 0.

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Excessive iodine can lead to goiters. However, the relationship between the water iodine concentration (WIC) and goiter rate (GR) is unclear. This study aims to explore the factors that influence children's GR in areas with high WIC and analyse the threshold value of the GR increase associated with the WIC.

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The is an important fruit pest in Chinese agricultural system. In current study, the complete mitochondrial genome of is determined. This mitogenome is 15,515 bp in size and comprises of 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and a control region.

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The long-legged fly belongs to the subfamily Xanthochlorinae of Dolichopodidae. The mitogenome of was sequenced, it is the first representative complete mitogenome from this subfamily. This mitogenome is 15,580 bp in size, includes 13 protein-coding genes, 22 transfer RNAs, and two ribosomal RNAs.

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The long-legged fly belongs to the subfamily Neurigoninae of Dolichopodidae. The mitogenome (GenBank accession number: MT921956) of was sequenced, the first representative complete mitogenome from this subfamily. The complete mitogenome is 17,141 bp, includes 13 protein-coding genes, 2 rRNAs, and 22 transfer RNAs.

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  • Dilated cardiomyopathy (DCM) is a serious heart condition linked to both genetic and environmental factors, with familial cases making up a significant portion of occurrences.
  • A study comparing 180 idiopathic DCM patients from Kazak and Han ethnic groups to healthy controls found significant genetic differences related to the TNNT2 gene, particularly involving the SNP rs3729547 variant.
  • The findings suggest that certain polymorphisms in the TNNT2 gene may increase the risk for DCM in these populations, highlighting the importance of genetic testing in understanding heart disease susceptibility.
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Objective: Detect the relationship between TPM1 gene mutations and dilated cardiomyopathy (DCM) of Kazaks and Hans in Xinjiang.

Methods: TPM1 gene was screened from 31 family members in a Kazak family with familiar DCM (FDCM), 100 patients with idiopathic DCM (IDCM, 50 Kazaks and 50 Hans), and in 100 healthy controls (50 Kazaks and 50 Hans). All the samples were the inpatients or outpatients of First Affiliated Hospital of Xinjiang University from 2012 to 2014.

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate pacemaker currents in the atrium. The microRNA (miR) families miR-1 and miR-133 regulate the expression of multiple genes involved in myocardial function, including HCN channels. It was hypothesized that age‑dependent changes in HCN2, HCN4, miR‑1 and miR‑133 expression may contribute to age‑associated atrial fibrillation, and therefore the correlation between expression levels, among adult (≤65 years) and aged patients (≥65 years), and sinus rhythm was determined.

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Background: Ivabradine is an inhibitor of mixed Na+-K+ current that could combine with HCN channels to reduce the transmembrane velocity of funny current (If), heart rate, and cardiac efficiency, and thus be used for the treatment of cardiovascular diseases such as chronic heart failure. As an ion channel blocker, Ivabradine is also a potential antiarrhythmic agent.

Material/methods: Twelve aging dogs (8-10 years old) underwent rapid atrial pacing for 2 months to induce age-related AF in this study.

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Background: We compared cardiac electrophysiological indicators and regional expression levels of cardiac hyperpolarization-activated cyclic nucleotide-gated (HCN) channels between adult and aged dogs to identify possible mechanisms of age-related atrial fibrillation.

Material/methods: Corrected sinus node recovery time (SNRTc) and effective refractory period (ERP) of the atrium and pulmonary veins were measured in 10 adult (3-6 years old) and 10 aged dogs (>9 years old). Expression levels of HCN2 and HCN4 channel mRNAs and proteins were measured in the sinoatrial node, atrium, and pulmonary veins by real-time PCR and Western blotting.

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