Background: With the rising costs for knee arthroplasty, therapies that allow patients to avoid or delay surgery following knee osteoarthritis (KOA) may help in reducing overall health care costs. Multiple intraarticular hyaluronic acid (HA) products are available on the market, varying by formulation, molecular weight, and number of injections, but clinical and economic benefits may differ by product. To evaluate the all-cause and KOA-related health care resource utilization (HCRU) and costs among newly diagnosed patients with KOA treated with multi-injection HA.
View Article and Find Full Text PDFJ Biomed Nanotechnol
September 2018
Silver nanoparticles (AgNPs) have attracted great attention in cancer theranostics due to their extraordinary physiochemical and biological properties. This review discusses a large number of papers and summarizes the recent applications of AgNPs in cancer theranostics from the following five perspectives: (1) desirable features of AgNPs for theranostic applications, (2) synthesis of AgNPs by physical, chemical, and biological processes, (3) applications of AgNPs in cancer theranostics in vitro, (4) applications of AgNPs in cancer theranostics in vivo, and (5) nanotoxicity of AgNPs. Furthermore, some views are discussed that concern the synthetic challenges, toxicity, and clinical translation of AgNPs and the future development of multifunctional theranostic platforms.
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