Publications by authors named "Yuto Okumura"
Objectives: Improving the lifestyle of occupational workers is essential for extending healthy life expectancy. We investigated various lifestyle-related items in a rural Japanese population and compared them between agricultural and non-agricultural workers.
Methods: This cross-sectional study was conducted as a part of the "Iwaki Health Promotion Project.
Article Synopsis
- The study investigates the differences and similarities in copy number variations (CNVs) related to bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD) using data from 8708 Japanese individuals.
- It reveals that BD has a greater burden of smaller exonic deletions, while SCZ and ASD show a prevalence of larger exonic CNVs, with notable differences in the effect sizes and distributions of these CNVs across disorders.
- Despite these differences, some shared molecular mechanisms, particularly in chromatin biology, were identified, and certain synaptic genes were linked to BD risk, suggesting potential pathways for further research into its causes.