Publications by authors named "Yuto Morishima"
Article Synopsis
- ALS is a serious neurodegenerative disease affecting motor neurons, primarily leading to respiratory failure, with no known cure.
- A systematic review was conducted examining existing studies on the profile of microRNAs found in extracellular vesicles (EVs) from the blood of ALS patients, including 11 studies with 263 patients primarily suffering from sporadic ALS.
- The review highlighted variations in methods for isolating EVs and analyzing microRNAs, noting the repeated identification of two specific microRNAs (miR-199a-3p and miR-199a-5p), but emphasized the need for more research to strengthen findings.
Article Synopsis
- A 54-year-old Japanese man developed headache and fever after receiving a SARS-CoV-2 vaccine, and within a week, he became deeply unconscious.
- MRI and cerebrospinal fluid tests revealed abnormal lesions in his brain, leading to a diagnosis of autoimmune GFAP-astrocytopathy (GFAP-A) with positive anti-GFAP antibodies.
- Despite treatment with steroids and immunoglobulin therapy, the patient's condition worsened, with further enlargement of brain lesions and atypical pathological findings showing inflammation and damage to neural cells.
Introduction: Uterine adenomyosis is a benign disorder in which endometrial glands and stroma are present within the myometrium. There have been several case reports of cerebral infarction associated with adenomyosis, but their clinical characteristics, optimal treatment, and prognosis have not been systematically reviewed.
Methods: A case of cerebral infarction with adenomyosis is reported, and a comprehensive systematic literature search using the PubMed database was conducted.
[A case of ataxic gait disturbance due to 1-bromopropane neurotoxicity].
Rinsho Shinkeigaku
January 2023
A 55-year-old man presented a slowly progressive sensory disorder, predominantly in both lower limbs, and gait disturbance. Neurological examinations revealed abnormal sensation and spasticity in both lower limbs, and a wide-based gait. Although examination revealed mild hyperchloremia and decreased motor conduction velocity in the peroneal nerve, head and whole spine MRI, and spinal fluid examination were normal.
View Article and Find Full Text PDFAge-related changes in blood pressure and heart rates of patients with Parkinson's disease.
J Clin Hypertens (Greenwich)
January 2021
This study evaluated yearly changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rates (HR) for patients with Parkinson's disease (PD). Data were collected for the last 10 years from medical records of 28 PD patients and 30 non-PD patients with other neurological disorders. Age-related changes in each group were analyzed by year using mean values of SBP, DBP, and HR obtained at their bi-monthly visits.
View Article and Find Full Text PDFArticle Synopsis
- Spastic paraplegia type 4 (SPG4) is the most common hereditary form of spastic paraplegia, caused by mutations in the SPAST gene.
- A Japanese patient with SPG4 was found to have a new mutation (p.R460L) in the SPAST gene that was not inherited from their parents.
- This case adds to the understanding of SPG4 by providing new clinical and genetic information.