Publications by authors named "Yuto Mochimaru"
Article Synopsis
- Bone marrow (BM) examination is crucial for diagnosing myelodysplastic syndromes (MDS), and proper sample collection is essential for accurate results.
- A study in Japan found that 32.5% of BM samples from MDS patients were massively haemodiluted, with 18.4% showing no BM particles at all.
- Many doctors failed to recognize the haemodilution, resulting in a significant number of BM biopsies not being performed, which could hinder accurate diagnosis and treatment.
Objectives: In myelodysplastic syndromes (MDS), neoplastic myeloblast (CD34+CD13+CD33+ cells) numbers often increase over time, leading to secondary acute myeloid leukemia (AML). In recent studies, blasts in some MDS patients have been found to express a megakaryocyte-lineage molecule, CD41, and such patients show extremely poor prognosis. This is the first study to evaluate whether myeloblasts transition to CD41+ blasts over time and to investigate the detailed immunophenotypic features of CD41+ blasts in MDS.
View Article and Find Full Text PDF