Publications by authors named "Yuto Kaneda"
Article Synopsis
- Cytokine release syndrome (CRS) is a common side effect of CAR-T cell therapy, which can sometimes manifest as localized CRS (L-CRS) affecting specific areas like the larynx.
- A 67-year-old woman with transformed follicular lymphoma experienced laryngeal edema after CAR-T treatment, requiring tracheal intubation due to inadequate response to standard treatments (tocilizumab and dexamethasone).
- Key takeaways include recognizing that CAR-T therapy can lead to serious L-CRS like laryngeal edema, that TCZ alone may not be effective for cervical L-CRS, and the importance of prompt management to prevent airway complications.
This study investigated the prognostic impact of vitamin D deficiency and reduced skeletal muscle mass in diffuse large B-cell lymphoma (DLBCL) patients. A retrospective analysis of 186 newly diagnosed DLBCL patients from 2012 to 2022 was conducted, measuring serum 25-hydroxyvitamin D [25(OH)D] levels and the skeletal muscle index (SMI). Decreased vitamin D levels were linked to more severe DLBCL disease, with a median 25(OH)D concentration of 13 (4.
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- Azacitidine (AZA) is a standard treatment for high-risk myelodysplastic syndromes (MDS), and this study explored how skeletal muscle depletion (SMD) impacts MDS patients undergoing this treatment.* -
- The study involved 50 MDS patients, evaluating muscle mass through CT imaging, revealing that 27 patients had SMD, with median survival slightly lower for those with SMD (13.4 months) compared to those without (15.2 months), though this difference wasn't statistically significant.* -
- Results indicated that while SMD did not significantly affect overall survival or response rates, it was linked to a higher frequency of serious anemia and thrombocytopenia in patients treated with AZA
Article Synopsis
- * The CONUT score was found to be an independent predictor of overall survival, with a hazard ratio of 1.11, and effectively stratified patients based on prognosis using a cutoff value of 3.
- * Additionally, the CONUT score influenced the initial dose intensity of treatment, indicating that nutritional status at diagnosis can affect treatment adjustments and overall outcomes for these patients.
Article Synopsis
- - The study compared the predictive capabilities of the International Prognostic Index (IPI) and the Prognostic Index for PTCL-U (PIT) in assessing survival rates for patients with peripheral T-cell lymphoma (PTCL).
- - Data from 113 patients showed that 5-year survival rates were similar for both indexes, indicating that neither model outperformed the other significantly in predicting outcomes.
- - Key factors affecting overall survival included a performance status of 2 or higher and the presence of two or more extranodal lesions, but overall, both IPI and PIT were deemed useful for predicting patient prognosis.
This phase II clinical trial aimed to evaluate the efficacy and safety of the combination therapy of bendamustine, cytarabine, and rituximab (BRAC) in patients with relapsed or refractory follicular lymphoma (FL) or mantle cell lymphoma (MCL). Thirteen patients were enrolled and received a median of 4 cycles (range 2-6) of BRAC. The complete response rate was 61.
View Article and Find Full Text PDFA 72-year-old man developed dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid (BP) during treatment for type 2 diabetes mellitus and was administered prednisolone (PSL, 0.5 mg/kg). Despite PSL treatment at a daily dose of 19 mg/day, purpura appeared on his bilateral forearms 3 months later.
View Article and Find Full Text PDFSarcopenia is a poor prognosis factor in some cancer patients, but little is known about the mechanisms by which malignant tumors cause skeletal muscle atrophy. Tryptophan metabolism mediated by indoleamine 2,3-dioxygenase is one of the most important amino acid changes associated with cancer progression. Herein, we demonstrate the relationship between skeletal muscles and low levels of tryptophan.
View Article and Find Full Text PDFA 30-year-old woman who was 14 weeks pregnant was admitted to our hospital due to purpura, nasal bleeding, and abdominal pain. She was diagnosed with acquired thrombotic thrombocytopenic purpura (TTP) based on the presence of hemolytic anemia, thrombocytopenia, decreased ADAMTS 13 activity (<0.01 IU/ml), and high ADAMTS 13 inhibitor levels (4.
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