Outstanding high-temperature capacitive performance in all-organic dielectrics enabled by synergistic optimization of molecular traps and aggregation structures.

Improving the high-temperature performance of polymer dielectrics is critical for the development of advanced electrical systems. The deterioration of the capacitive performance of polymer dielectrics at high electric fields and elevated temperatures is attributable to the exponentially increased conduction loss. Herein, a synergistic strategy of molecular trap and aggregation structure optimization is developed to suppress the conduction loss of polymer dielectrics.

Prediction of 90 day readmission in heart failure with preserved ejection fraction by interpretable machine learning.

Aims: Certain critical risk factors of heart failure with preserved ejection fraction (HFpEF) patients were significantly different from those of heart failure with reduced ejection fraction (HFrEF) patients, resulting in the limitations of existing predictive models in real-world situations. This study aimed to develop a machine learning model for predicting 90 day readmission for HFpEF patients.

Methods And Results: Data were extracted from electronic health records from 1 August 2020 to 1 August 2021 and follow-up records of patients with HFpEF within 3 months after discharge.

Robust Electrostatic-Templated Polymerization for Controllable Synthesis of Stable and Permeable Polyelectrolyte Vesicles.

Polymer vesicles are of profound interest for designing delivery vehicles and nanoreactors toward a variety of biomedical and catalytic applications, yet robust synthesis of stable and permeable vesicles remains challenging. Here, we propose an electrostatic-templated polymerization that enables fabrication of polyelectrolyte vesicles with simultaneously regulated stability and permeability. In our design, cationic monomers were copolymerized with cross-linkers in the presence of a polyanionic-neutral diblock copolymer as a template.

Electrostatically Mediated In Situ Polymerization for Enzyme Immobilization and Activation.

Enzyme immobilization in nanoparticles is of interest for boosting their catalytic applications, yet rational approaches to designs achieving both high enzyme loading and activation remain a challenge. Herein, we report an electrostatically mediated in situ polymerization strategy that simultaneously realizes enzyme immobilization and activation. This was achieved by copolymerizing cationic monomers with a cross-linker in the presence of the enzyme lipase (anionic) as the template, which produces enzyme-loaded nanogels.

Effects of Control Factors on Protein-Polyelectrolyte Complex Coacervation.

Protein-polyelectrolyte complex coacervation is of particular interest for mimicking intracellular phase separation and organization. Yet, the challenge arises from regulating the coacervation due to the globular structure and anisotropic distributed charges of protein. Herein, we fully investigate the different control factors and reveal their effects on protein-polyelectrolyte coacervation.

Exploring causal mechanisms and essential factors in the prevention and control of chlamydia in Guangdong, Southern China: a study protocol.

Background: Chlamydia Trachomatis (CT) is among the most prevalent sexually transmitted diseases (STDs) globally. According to the World Health Organization, more than 131 million people get infected with CT annually. CT is usually transmitted via sexual contact or perinatal exposure and can result in severe long-term complications.

Paeonol repurposing for cancer therapy: From mechanism to clinical translation.

Paeonol (PAE) is a natural phenolic monomer isolated from the root bark of Paeonia suffruticosa that has been widely used in the clinical treatment of some inflammatory-related diseases and cardiovascular diseases. Much preclinical evidence has demonstrated that PAE not only exhibits a broad spectrum of anticancer effects by inhibiting cell proliferation, invasion and migration and inducing cell apoptosis and cycle arrest through multiple molecular pathways, but also shows excellent performance in improving cancer drug sensitivity, reversing chemoresistance and reducing the toxic side effects of anticancer drugs. However, studies indicate that PAE has the characteristics of poor stability, low bioavailability and short half-life, which makes the effective dose of PAE in many cancers usually high and greatly limits its clinical translation.

Protein separation by sequential selective complex coacervation.

In food manufacturing and particular biomedical products selected proteins are often required. Obtaining the desired proteins in a pure form from natural resources is therefore important, but often very challenging. Herein, we design a sequential coacervation process that allows to efficiently isolate and purify proteins with different isoelectric points (pIs) from a mixed solution, namely Bovine Serum Albumin (BSA, pI = 4.

Validity of patients' online reviews at direct-to-consumer teleconsultation platforms: a protocol for a cross-sectional study using unannounced standardised patients.

Introduction: As direct-to-consumer teleconsultation (hereafter referred to as 'teleconsultation') has gained popularity, an increasing number of patients have been leaving online reviews of their teleconsultation experiences. These reviews can help guide patients in identifying doctors for teleconsultation. However, few studies have examined the validity of online reviews in assessing the quality of teleconsultation against a gold standard.

Rational design of polymeric nanozymes with robust catalytic performance via copper-ligand coordination.

Incorporating copper (Cu) ions into polymeric particles can be a straightforward strategy for mimicking copper enzymes, but it is challenging to simultaneously control the structure of the nanozyme and of the active sites. In this report, we present a novel bis-ligand (L) containing bipyridine groups connected by a tetra-ethylene oxide (4EO) spacer. In phosphate buffer the Cu-L mixture forms coordination complexes that (at proper composition) can bind polyacrylic acid (PAA) to produce catalytically active polymeric nanoparticles with well-defined structure and size, which we refer to as 'nanozymes'.

Kinetic Characterization and Catalytic Mechanism of -Acetylornithine Aminotransferase Encoded by Gene from sp. PCC6803.

The enzyme encoded by gene from sp. PCC6803 was reported to function as -acetylornithine aminotransferase, γ-aminobutyric acid aminotransferase, and ornithine aminotransferase, which played important roles in multiple metabolic pathways. Among these functions, -acetylornithine aminotransferase catalyzes the reversible conversion of -acetylornithine to -acetylglutamate-5-semialdehyde with PLP as cofactor, which is a key step in the arginine biosynthesis pathway.

E2SCNet: Efficient Multiobjective Evolutionary Automatic Search for Remote Sensing Image Scene Classification Network Architecture.

Remote sensing image scene classification methods based on deep learning have been widely studied and discussed. However, most of the network architectures are directly reliant on natural image processing methods and are fixed. A few studies have focused on automatic search mechanisms, but they cannot weigh the interpretation accuracy and the parameter quantity for practical application.

Research on the Necessity of AIDS Intervention for College Students Based on Cognitive Behavioral Therapy.

Background: Despite abundant research on AIDS prevention and intervention, many residual factors influence the actual impact of the intervention at a population level. Misconceptions held by subjects lead to patterns of behavior, which do not reflect levels of cognition.

Methods: Cognition and behavioral patterns relating to HIV were investigated without intervention in freshmen before and after a two-year study period.

An Accurate UAV 3-D Path Planning Method for Disaster Emergency Response Based on an Improved Multiobjective Swarm Intelligence Algorithm.

Planning a practical three-dimensional (3-D) flight path for unmanned aerial vehicles (UAVs) is a key challenge for the follow-up management and decision making in disaster emergency response. The ideal flight path is expected to balance the total flight path length and the terrain threat, to shorten the flight time and reduce the possibility of collision. However, in the traditional methods, the tradeoff between these concerns is difficult to achieve, and practical constraints are lacking in the optimized objective functions, which leads to inaccurate modeling.

Synthesis of Anionic Nanogels for Selective and Efficient Enzyme Encapsulation.

Polyelectrolyte nanogels containing cross-linked ionic polymer networks feature both soft environment and intrinsic charges which are of great potential for enzyme encapsulation. In this work, well-defined poly(acrylic acid) (PAA) nanogels have been synthesized based on a facile strategy, namely, electrostatic assembly directed polymerization (EADP). Specifically, AA monomers are polymerized together with a cross-linker in the presence of a cationic-neutral diblock copolymer as the template.

Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.

Background: Short-term starvation (STS) has gradually been confirmed as a treatment method that synergistically enhances the effect of chemotherapy on malignant tumours. In clinical applications, there are still some limitations of poly (ADP-ribose) polymerase inhibitors (PARPi), including understanding their effectiveness and side effects. Here, we sought to investigate the effect and mechanism of the combined use of STS and niraparib in the treatment of ovarian cancer.

Low Serum LH Levels During Ovarian Stimulation With GnRH Antagonist Protocol Decrease the Live Birth Rate After Fresh Embryo Transfers but Have No Impact in Freeze-All Cycles.

Objective: To explore the association between serum LH levels and the cumulative live birth rate (CLBR) within one complete cycle, and the impact of serum LH levels on the live birth rate (LBR) after the initial embryo transfer (ET) considering different ET strategies (fresh or freeze-all).

Design: A retrospective cohort study.

Setting: University-affiliated reproductive center.

Multiobjective Sine Cosine Algorithm for Remote Sensing Image Spatial-Spectral Clustering.

Remote sensing image data clustering is a tough task, which involves classifying the image without any prior information. Remote sensing image clustering, in essence, belongs to a complex optimization problem, due to the high dimensionality and complexity of remote sensing imagery. Therefore, it can be easily affected by the initial values and trapped in locally optimal solutions.

Effect of luteinizing hormone concentration on transcriptome and subcellular organelle phenotype of ovarian granulosa cells.

Research Question: Granulosa cells (GCs) surrounding oocytes are crucial for follicular growth, oocyte development, ovulation, and luteinization under the dynamic co-stimulation of follicle stimulating hormone (FSH) and luteinizing hormone (LH). This study aimed to investigate the effect of LH levels on GCs in preovulatory follicles under gonadotropin releasing hormone antagonist-based ovarian stimulation. In vitro experiments were also conducted to study the direct effect of LH on GCs.

Functional divergence and intron variability during evolution of angiosperm TERMINAL FLOWER1 (TFL1) genes.

The protein encoded by the TERMINAL FLOWER1 (TFL1) gene maintains indeterminacy in inflorescence meristem to repress flowering, and has undergone multiple duplications. However, basal angiosperms have one copy of a TFL1-like gene, which clusters with eudicot TFL1/CEN paralogs. Functional conservation has been reported in the paralogs CENTRORADIALIS (CEN) in eudicots, and ROOTS CURL IN NPA (RCNs) genes in monocots.

Asymmetric introgression in the horticultural living fossil cycas sect. Asiorientales using a genome-wide scanning approach.

The Asian cycads are mostly allopatric, distributed in small population sizes. Hybridization between allopatric species provides clues in determining the mechanism of species divergence. Horticultural introduction provides the chance of interspecific gene flow between allopatric species.

Microencapsulation of menhaden fish oil containing soluble rice bran fiber using spray drying technology.

Emulsion (EFMO) containing purified menhaden oil (PMO) and soluble rice bran fiber (SRBF) was dried in a pilot scale spray dryer and produced microencapsulated PMO with SRBF (MFMO). EFMO had well isolated spherical droplets with the size of 1 to 10 μm and showed pseudoplastic fluid and viscoelastic characteristics. EFMO had lower lipid oxidation than the emulsion containing PMO without SRBF when both emulsions were stored at 20 and 40 °C for 88 h, which indicated that the SRBF reduced the lipid oxidation in the EFMO.

Functional properties of protein fractions of channel catfish (Ictalurus punctatus) and their effects in an emulsion system.

This study demonstrated the feasibility of producing soluble protein (CFSP) and insoluble protein (CFISP) fractions from catfish muscle protein. CFSP and CFISP contained 60.6% and 73.