Publications by authors named "Yuting Su"

Lipid reprogramming in carcinoma is reported to have a role in carcinogenesis, prognosis and therapy response. The lipid reprogramming could be contributed by either autonomous or nonautonomous resources. Since the nonautonomous lipid resources contributed by lipoproteins and their receptors have been reported in epithelial ovarian cancer (EOC), the impact of autonomous lipid metabolites was unknown.

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Background & Aims: Dysregulation of one-carbon metabolism is considered an early hallmark of mitochondrial dysfunction and cancer metabolism. ALDH1L2 belongs to the aldehyde dehydrogenase family and plays an important role in tumor progression. However, little is known about the precise role and underlying mechanisms of ALDH1L2 in hepatocellular carcinoma (HCC).

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Quercetin, a promising anti-inflammatory agent, faces challenges related to poor bioavailability and limited practical applications. β-glucan, a natural polysaccharide, can be specifically recognized by macrophages, making it an ideal targeting carrier to enhance therapeutic efficacy for macrophage-related dysfunctions. In this study, β-glucan conjugated quercetin nano-complexes (CM-Cur@QT) were developed to target macrophage and alleviate pro-inflammatory response in M1-like macrophages.

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Ethnopharmacological Relevance: Sjögren's syndrome (SJS) and dry eye syndrome (DES) are characterized by ocular dryness from inadequate tear production or excessive evaporation. To evaluate the effectiveness of TBDESJS (Chun-Yu-Ching-Hua-Yin, CYCHY), a TCM tea bag, in treating SJS and DES patients compared with healthy controls (NHC).

Materials And Methods: This phase II pilot study included 100 participants (60 SJS, 30 DES, 10 NHC) across 8 weeks, assessing changes in Schirmer's test, OSDI, ESSPRI, PSQI, FIRST, and artificial tear usage, using repeated measurement ANOVA and Tukey's honestly significant difference (HSD) for analysis.

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The dissemination of antibiotic resistance genes (ARGs) through plasmids is a major mechanism for the development of bacterial antimicrobial resistance. The adaptation and evolution mechanisms of multidrug-resistant (MDR) plasmids with their hosts are not fully understood. Herein, we conducted experimental evolution of a 244 kb MDR plasmid (pJXP9) under various conditions including no antibiotics and mono- or combinational drug treatments of colistin (CS), cefotaxime (CTX), and ciprofloxacin (CIP).

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Background: Ovarian cancer (OC) is the most malignant gynecologic cancer, and chemoresistance is a major cause of treatment failure in patients with OC. The understanding of microRNA (miRNA) in cancer is limited, and the role of miRNA (miR)-450b-5p in cancer drug resistance is unknown. In this study, we aim to evaluate the role of miR-450b-5p in drug-resistant OC and its underlying mechanisms.

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Background: Ovarian cancer (OC) is a kind of lethiferous cancer in gynecology, and the development of chemoresistance is the brief reason for treatment failure. The genes which contribute to chemoresistance are often leading to short survival. Thus, this study aims to identify predictive markers for chemoresistance and survival from chemoresistant-related genes.

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Article Synopsis
  • The study investigates how two genes, PagHAM4a and PagHAM4b, regulate the formation of secondary xylem, which is crucial for tree biomass production.
  • Overexpressing these genes boosts cambial activity and increases the number of xylem cells, while mutations lead to decreased activity and reduced xylem.
  • The research uncovers distinct gene networks controlled by PagHAM4a and PagHAM4b, highlighting their roles in promoting cambial differentiation into secondary xylem.
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  • Epilepsy is a common neurological disorder linked to endoplasmic reticulum stress (ERS) and oxidative stress (OS), with cysteine (Cys) playing a potential role in these processes.
  • Researchers developed a new fluorescent probe called BFC that effectively targets the endoplasmic reticulum, allowing for quick and sensitive detection of Cys levels (3 minutes response time, low detection limit).
  • The BFC probe demonstrated low toxicity and was successful in monitoring Cys levels in both zebrafish models of epilepsy and various food samples, even enabling smartphone-assisted detection for practical use.
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Background: Intrauterine adhesions (IUA) are a challenging clinical problem in reproductive infertility. The most common causes are intrauterine surgery and abortions. We aimed to investigate whether early second-look office hysteroscopy can prevent IUA.

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Candida albicans is a leading cause of intravascular catheter-related infections. The capacity for biofilm formation has been proposed to contribute to the persistence of this fungal pathogen on catheter surfaces. While efforts have been devoted to identifying microbial factors that modulate C.

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  • Researchers discovered a strain of Kunming mice (KM) displaying symptoms similar to Usher Syndrome, including abnormal electroretinogram (ERG) readings and high auditory brainstem response (ABR) thresholds, by crossbreeding KM with CBA/CaJ mice.
  • This study involved analyzing the offspring from crossbreeding KM with CBA/J mice using various methods like ERG readings, ABR tests, and genetic analyses to assess their phenotypes and genotypes.
  • Results indicated that F1 hybrid mice had no ERG waveforms but normal ABR results, while F2 hybrids (J1 and J2) showed different hearing loss traits, with J1 mice presenting a retinitis pigmentosa phenotype and significant gene
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Background: Mounting evidences shows that the ubiquitin‒proteasome pathway plays a pivotal role in tumor progression. The expression of 26S proteasome non-ATPase regulatory subunit 9 (PSMD9) is correlated with recurrence and radiotherapy resistance in several tumor types. However, the role and mechanism of PSMD9 in hepatocellular carcinoma (HCC) progression remain largely unclear.

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Despite neoadjuvant chemoradiotherapy (CRT) being the established standard for treating advanced rectal cancer, clinical outcomes remain suboptimal, necessitating the identification of predictive biomarkers for improved treatment decisions. Previous studies have hinted at the oncogenic properties of the Fc fragment of IgG binding protein (FCGBP) in various cancers; however, its clinical significance in rectal cancer remains unclear. In this study, we first conducted an analysis of a public transcriptome comprising 46 rectal cancer patients.

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Protein glycation in human body is closely linked to the onset/progression of diabetes associated complications. These glycated proteins are commonly known as advanced glycation end products (AGEs). Recent literature has also highlighted the involvement of AGEs in other non-communicable diseases (NCDs) such as cardiovascular, cancer, and Alzheimer's diseases and explored the impact of plant metabolites on AGEs formation.

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Unlabelled: The Hippo kinases MST1 and MST2 initiate a highly conserved signaling cascade called the Hippo pathway that limits organ size and tumor formation in animals. Intriguingly, pathogens hijack this host pathway during infection, but the role of MST1/2 in innate immune cells against pathogens is unclear. In this report, we generated knockout macrophages to investigate the regulatory activities of the Hippo kinases in immunity.

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Chia seeds have gained significant attention due to their unique composition and potential health benefits, including high dietary fibers, omega-3 fatty acids, proteins, and phenolic compounds. These components contribute to their antioxidant, anti-inflammatory effects, as well as their ability to improve glucose metabolism and dyslipidemia. Germination is recognized as a promising strategy to enhance the nutritional value and bioavailability of chia seeds.

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Treatment for inflammatory bowel disease (IBD) is challenging since current anti-inflammatory and immunosuppressive therapies do not address the underlying causes of the illness, which include increased levels of reactive oxygen species (ROS) and dysbiosis of the gut commensal microbiota. Additionally, these treatments often have systemic off-target effects and adverse side effects. In this study, we have developed a prebiotic yeast β-glucan nanocomplex coated with bio-adhesive polydopamine (YBNs@PDA) to effectively prolong their retention time in the gastrointestinal (GI) tract.

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Little is known about the factors regulating carotenoid biosynthesis in roots. In this study, we characterized DCAR_032551, the candidate gene of the Y locus responsible for the transition of root color from ancestral white to yellow during carrot (Daucus carota) domestication. We show that DCAR_032551 encodes a REPRESSOR OF PHOTOSYNTHETIC GENES (RPGE) protein, named DcRPGE1.

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Purpose: This study presents a novel technique for intraocular lens (IOL) fixation. The technique can be used on single-piece acrylic IOLs and can manage patients who are either with aphakia or with a dislocated IOL.

Methods: One end of the Gore-Tex suture is tied into the optic-haptic junction of the IOL.

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Article Synopsis
  • The study examined miscarriage rates in patients with poor ovarian response categorized by the POSEIDON criteria, identifying four distinct subgroups with varying success rates in assisted reproductive technology.
  • A total of 1222 clinical pregnancies from POSEIDON patients revealed miscarriage rates ranging from 11.7% to 37.5% across the different subgroups, with advanced maternal age identified as a key risk factor for miscarriage.
  • Although diminished ovarian reserve (DOR) was associated with increased miscarriage risks, it did not significantly impact the outcomes in POSEIDON patients, suggesting age is a more critical concern.
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Background: Sjögren's Syndrome (SS), mainly affecting women in their midlife, is characterized by persistent inflammation in glands producing tears and saliva, often leading to significant complications. This study investigates the differences in autonomic system functioning between individuals with SS and healthy controls.

Methods: From April 2019 to December 2022, 329 diagnosed primary SS (pSS) patients and 30 healthy controls were enrolled at Taipei Veterans General Hospital, Taipei, Taiwan.

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