Tiaogan Jiejiu Tongluo formula alleviates hepatic steatosis in NAFLD mice by regulating AMPK signaling pathway.

Objectives: Tiaogan Jiejiu Tongluo formula (TJTF) is a traditional Chinese medicine formula for liver disease. The purpose of this study was to explore the protective effects and mechanisms of TJTF on nonalcoholic fatty liver disease (NAFLD) mice.

Methods: A NAFLD model of mice was established by a combination of a high-fat diet and CCL4 and then treated with TJTF.

Differences and driving factors of leaf functional traits between old tree and mature tree of Pinus tabulaeformis in the Loess Plateau.

Background: Study the leaf functional traits is highly important for understanding the survival strategies and climate adaptability of old trees. In this study, the old (over 100 years old) and mature trees (about 50 years old) of Pinus tabulaeformis in the Loess Plateau were studied, and the variation of 18 leaf functional traits (6 economic, 4 anatomical, 2 photosynthetic and 6 physiological traits) was analyzed to understand the differences of survival strategies between old and mature trees. Combined with transcriptome and simple sequence repeats (SSR) techniques, the effects of soil property factors and genetic factors on leaf functional traits and the potential molecular mechanisms of traits differences were studied.

Genetic Diversity Analysis and Polyploid Induction Identification of .

from Sichuan is a valuable germplasm with high economic potential, but it faces variety scarcity. To address this, this study collected 16 varieties (lines), identifying IpHT1 as a promising parent due to its high oil content (38.5%) and red fruits.

Cover crop rotation suppresses root-knot nematode infection by shaping soil microbiota.

Cover crop integration into grain crop rotations is a promising strategy for mitigating nematode-induced diseases in agriculture. However, the precise mechanisms underlying this phenomenon remain elusive. Here, we first assessed the impact of five commonly used cover crops on the suppression of rice root-knot nematodes (RKNs).

Evaluation and mechanistic analysis of the effect of the addition of alkaline earth metal CaO on Cd solidification enhancement in lightweight aggregate preparation.

The volatilization of Cd during the preparation of lightweight aggregates (LWAs) can cause serious damage to the environment, so a method to harmlessly transform Cd during this process is required. In this regard, the alkaline earth metal CaO was added to Cd-containing aggregate raw materials for treatment, and the effect of CaO addition on the properties of LWAs in the presence of chlorine and sulfate was investigated. Kinetic models of the Cd volatilization were established by using the Arrhenius equation to predict the volatilization of Cd at different sintering stages.

Morin alleviates DSS-induced ulcerative colitis in mice via inhibition of inflammation and modulation of intestinal microbiota.

Ulcerative colitis (UC) is a chronic inflammatory condition with recurrent and challenging symptoms. Effective treatments are lacking, making UC management a critical research area. Morin (MO), a flavonoid from the Moraceae family, shows potential as an anti-UC agent, but its mechanisms are not fully understood.

Comprehensive analysis and identification of subtypes and hub genes of high immune response in lung adenocarcinoma.

Background: The advent of immunotherapy targeting immune checkpoints has conferred significant clinical advantages to patients with lung adenocarcinoma (LUAD); However, only a limited subset of patients exhibit responsiveness to this treatment. Consequently, there is an imperative need to stratify LUAD patients based on their response to immunotherapy and enhance the therapeutic efficacy of these treatments.

Methods: The differentially co-expressed genes associated with CD8 + T cells were identified through weighted gene co-expression network analysis (WGCNA) and the Search Tool for the Retrieval of Interacting Genes (STRING) database.

Karyotype and Phylogenetic Relationship Analysis of Five Varieties and Cultivars of Based on Oligo-FISH.

Green prickly ash () has edible and medicinal value and is an economically significant plant in many countries. has many cultivars and varieties with similar phenotypes that are difficult to distinguish via traditional methods. In this study, we utilized oligo-FISH to distinguish five varieties and cultivars of on the basis of three oligonucleotide probes of 5S rDNA, (AGT), and (GAA).

Study on Photochemical Properties of a Sr-SnS/CaInS Heterostructure to Improve Cr(VI) Removal.

Compound semiconductor photocatalysis technology is considered to be a promising treatment for solving water problems efficiently. The point of designing high-efficiency catalysts is to optimize the band gap structure and facilitate the separation of charge carriers by establishing new electron migration pathways. Recently, 3D porous CaInS was found to have good photocatalytic ability.

Electrochemically Exfoliated Graphene Oxide for Simple Fabrication of Cocaine Aptasensors.

Transducers made from graphene-type materials are widely used in sensing applications. However, utilization of graphene oxide obtained from electrochemical exfoliation of graphite (EGO) has remained relatively unexplored. In this study, electrochemical cocaine aptasensors based on large-size EGO flakes were investigated.

Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats.

Ethnopharmacological Relevance: Tiaogan Jiejiu Tongluo Formula (TJTF), a traditional Chinese medicine formula, is modified from the well-known ancient prescription Danzhi-Xiaoyao Powder (DXP). Owing to its ability to regulate liver, strengthen spleen, detoxicating, and dredge collaterals in Chinese medicine, TJTF is usually used to treat anxiety, hypertension, alcoholic fatty liver disease in clinical application. However, the protective effect and potential molecular mechanism of TJTF on alcoholic liver injury has not fully been clarified.

FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila.

Knowledge of adipogenetic mechanisms is essential to understand and treat conditions affecting organismal metabolism and adipose tissue health. In Drosophila, mature adipose tissue (fat body) exists in larvae and adults. In contrast to the well-known development of the larval fat body from the embryonic mesoderm, adult adipogenesis has remained mysterious.

High ambient temperature increases the number of emergency visits for upper urolithiasis in Hefei City, China.

Background: Few studies have examined the effect of ambient temperature on upper urolithiasis in developing countries, with even fewer considering individual factors.

Methods: The present study analyzed data on emergency department visits for upper urolithiasis from three hospital sites of a large hospital in Hefei, China, during 2016-2020. Data on environmental factors during the same period were also analyzed.

Comparing the efficacy and safety of different analgesic strategies after open hemorrhoidectomy: a systematic review and network meta-analysis.

Purpose: To evaluate the clinical efficacy and safety of different analgesic interventions in the treatment of pain after open hemorrhoidectomy by systematic review and network meta-analysis.

Methods: Randomized controlled trials that met the inclusion criteria in PubMed, Cochrane Library, Embase, Web of Science, Scopus, CNKI, WANFANG DATA, and VIP were searched from the date of database construction to June 28, 2022.

Results: Among the 13 randomized controlled trials (RCTs), 731 patients were included in the network meta-analysis.

Five Species of Karyotype Based on Oligo-FISH for 5S rDNA and (AGT).

As a relict plant, is used in a variety of medicinal ingredients, for instance to treat a variety of cancers. plants are difficult to distinguish from one another due to their similar morphology; indeed, some species of cytogenetic data still are unclear. Oligo-FISH can rapidly and efficiently provide insight into the genetic composition and karyotype.

One-Step Synthesis of Aminobenzoic Acid Functionalized Graphene Oxide by Electrochemical Exfoliation of Graphite for Oxygen Reduction to Hydrogen Peroxide and Supercapacitors.

Graphene-based materials have attracted considerable attention as promising electrocatalysts for the oxygen reduction reaction (ORR) and as electrode materials for supercapacitors. In this work, electrochemical exfoliation of graphite in the presence of 4-aminebenzoic acid (4-ABA) is used as a one-step method to prepare graphene oxide materials (EGO) functionalized with aminobenzoic acid (EGO-ABA). The EGO and EGO-ABAs materials were characterized by FT-IR spectroscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, X-ray diffraction and scanning electron microscopy.

The AMPK pathway in fatty liver disease.

Lipid metabolism disorders are the primary causes for the occurrence and progression of various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) caused by a high-fat diet and ethanol. AMPK signaling pathway plays an important role in ameliorating lipid metabolism disorders. Progressive research has clarified that AMPK signal axes are involved in the prevention and reduction of liver injury.

ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism.

Obesity-related glomerulopathy is a secondary glomerular disease and its incidence has been increased globally in parallel with the obesity epidemic. ORG emerged as a growing cause of end-stage renal disease in recent years. Unbalanced production of adipokines at the adipose tissue as well as low-grade inflammatory processes play central roles in ORG progression.

Flexible, Transparent, and Hazy Composite Cellulosic Film with Interconnected Silver Nanowire Networks for EMI Shielding and Joule Heating.

An optical transparent and hazy film with admirable flexibility, electromagnetic interference (EMI) shielding, and Joule heating performance meeting the requirements of optoelectronic devices is significantly desirable. Herein, a cellulose paper was infiltrated by epoxy resin to fabricate a transparent cellulose paper (TCP) with high transparency, optical haze, and favorable flexibility, owing to effective light scattering and mechanical enhancement of the cellulose network. Moreover, a highly connected silver nanowire (AgNW) network was constructed on the TCP substrate by the spray-coating method and appropriate thermal annealing technique to realize high electrical conductivity and favorable optical transmittance of the composite film at the same time, followed by coating of a polydimethylsiloxane (PDMS) layer for protection of the AgNW network.

Boosting algorithm improves the accuracy of juvenile forensic dental age estimation in southern China population.

Age estimation based on the mineralized morphology of teeth is one of the important elements of forensic anthropology. To explore the most suitable age estimation protocol for adolescents in the South China population, 1477 panoramic radiograph images of people aged 2-18 years in the South were collected and staged by the Demirjian mineralization staging method. The dental ages were estimated using the parameters of the Demirjian and Willems.

The Genetic Diversity of spp. Based on SLAF-seq and Oligo-FISH.

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Spatial Patterns and Composition Traits of Soil Microbial Nitrogen-Metabolism Genes in the Forests at a Regional Scale.

Microbial-driven processes related to the nitrogen-metabolism (N-metabolism) in soil are critical for ecosystem functioning and stability. There are spatial patterns of microbial-mediated nitrogen processes, but we still lack an overview of the soil N-metabolism genes of single nitrogen-fixing tree species pure forests at a regional scale. Here, we investigated the spatial variation and drivers of microbial N-metabolism genes in the rhizosphere soil of on the Loess Plateau by metagenomic technology.