SMT-like esophageal squamous cell carcinoma (ESCC) is a rare form of esophageal cancer that can be easily misdiagnosed due to its endoscopic appearance resembling benign subepithelial lesions and often negative biopsy results.
A study involving six patients analyzed clinicopathological data and performed endoscopic ultrasound (EUS) and immunohistochemical tests on tumor tissues to identify specific markers associated with this cancer.
Results showed that EUS revealed distinct nonuniform lesions indicating cancer, with EUS-guided fine needle aspiration (EUS-FNA) confirming the diagnosis; the tumors exhibited a specific immune marker profile that suggests they might originate from submucosal glands.
The study evaluates the effectiveness of the depth-predicting score (DPS) and simplified depth-predicting score (S-DPS) in predicting the invasion depth of early gastric cancer by nonexpert endoscopists using conventional endoscopic images.
Results show that the S-DPS had higher diagnostic accuracy (73.86%) and specificity (92.42%) compared to DPS (67.05% accuracy and 71.21% specificity) when predicting invasion depth.
The findings suggest that S-DPS is not only more accurate but also simpler, enhancing its potential for clinical use by nonexpert endoscopists.