RBM47 as a potential therapeutic target for thyroid-associated ophthalmopathy.

RNA-binding motif 47 (RBM47) is a recently identified RNA-binding protein involved in early vertebrate development, immune homeostasis, and cancer development. This study examined the biological functions of RBM47 in thyroid-associated ophthalmopathy (TAO). Orbital fibroblasts (OFs) were obtained from the control (n = 6) and TAO groups (n = 6).

EMYWAY Workplace-Based Entrustable Professional Activities Assessments in Otolaryngology Residency Training: A Nationwide Experience.

Objective: To present workplace-based entrustable professional activities (EPAs) assessment data from the first 2 years of the EMYWAY platform in otolaryngology residency training in Taiwan.

Study Design: Two-year cross-sectional study.

Setting: Otolaryngology training programs.

Typical endocrine disrupting chemicals in newborns with congenital hypothyroidism: Concentrations, exposure assessment, and potential risks.

Congenital hypothyroidism (CH) has been reported as a prevalent endocrine disorder in newborns. Endocrine disrupting chemicals (EDCs) have been widely detected in humans and can influence endocrine function, especially thyroid function, and neonates as a susceptible population may be more prone to suffer from CH through exposure to various EDCs. In this study, the concentrations and composition profiles of several typical EDCs were determined in 266 serum samples collected from newborns with (n = 136) and without CH (n = 130) in Beijing, China from 2018 to 2020.

Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats.

Background: Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may cause fecal incontinence and lower quality of life due to large surgical wounds and potential sphincter damage. Human umbilical cord-derived MSCs (hUC-MSCs) and their exosomes (hUCMSCs-Exo) may promote wound healing.

Methods: This study assessed the efficacy, mechanisms, and safety of these exosomes in treating complex perianal fistulas in SD rats.

Concept and framework of digital twin human geographical environment.

The human geographical environment is a comprehensive setting formed by the interaction between human activities and the geographical environment, characterized by its complexity and vulnerability. Applying the digital twin method to create a new research model in a human geographical environment holds significant academic and practical value. This approach helps avoid disturbances in the real environment, deeply explores complex issues, and optimizes solutions for real-world geographical problems.

DHA Improves neurodevelopmental abnormalities in offspring of gestational diabetes mellitus patients via the PPAR-γ/FATP4 pathway.

Offspring of women with gestational diabetes mellitus (GDM) face an increased risk of long-term neurodevelopmental abnormalities. This study explores the altered expression of key placental fatty acid transport proteins-FATP2, FATP4, FATP6, FABP4, and FAT/CD36-in GDM patients, and the potential of docosahexaenoic acid (DHA) to mitigate neurodevelopmental risks in offspring by enhancing their expression through activation of peroxisome proliferator-activated receptor γ (PPAR-γ). Our findings demonstrate that placental FATP4 expression is reduced in GDM patients.

Enhanced flame retardancy of polyurethane foam with alginate-based flame-retardant coating.

Polyurethane (PU) foam is widely used in industrial and civil fields, but it is highly flammable. An eco-friendly flame-retardant coating has been fabricated from sodium alginate (SA) and mica powder, it has been applied to PU foam using a facile direct dip coating method, followed by crosslinking with Ca and modification with polydimethylsiloxane (PDMS), respectively. The original porous network structure is maintained in the coated PU (SMPU) foam with a porosity of 90.

Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening through MFN1.

Cellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions. Glutaminase 1 (GLS1), a key enzyme in the glutaminolysis pathway, has been implicated in various cellular senescence processes.

Potential molecular mechanisms of tobacco smoke exposure in Alzheimer's disease.

Background: Smoking is detrimental to health, with tobacco use being a critical factor in the development of various neurodegenerative diseases, including Alzheimer's disease (AD), which progressively impairs brain function and poses a significant threat to public health. This study aims to examine the potential genetic alterations induced by smoking that are associated with AD and to investigate the underlying regulatory mechanisms. The research will provide theoretical foundations for targeted prevention and treatment strategies for AD.

Microbial community and functional shifts across agricultural and urban landscapes within a Lake Erie watershed.

The role of sediment microbial communities in regulating the loss and retention of nutrients in aquatic ecosystems has been increasingly recognised. However, in the Great Lakes, where nutrient mitigation focuses on harmful algal blooms, there are limited studies examining the fundamental role of water/sediment microbes in nutrient biogeochemical cycling. Little is understood in this regard considering the increase in anthropogenic pressure on in-stream biological processes impacting nutrient flux to lakes.

Supramolecular Assembly, Solvent-Induced, and Mechanochromic Luminescence of Au(I) Quinoline-8-thiolates.

AuCl(PMe) and AuCl(PEt) were used to react with quinoline-8-thiolate (8-QNS) to give three Au(I) complexes, i.e., [8-QNS(AuPMe)]ClO (), [(8-QNS)Ag(AuPMe)]ClO (), and [8-QNS(AuPEt)]ClO (), which have been structurally determined by X-ray diffraction to show various intra- and intermolecular metal···metal contacts (i.

Immune regulation and organ damage link adiponectin to sepsis.

Sepsis is a life-threatening syndrome characterized by organ dysfunction, resulting from an uncontrolled or abnormal immune response to infection, which leads to septicemia. It involves a disruption of immune homeostasis, marked by the release of Inflammatory factors and dysfunction of immune cells. Adiponectin is widely recognized as an anti-inflammatory mediator, playing a crucial role in regulating immune cell function and exerting protective effects on tissues and organs.

Outcomes of cerebrovascular disease in muscular dystrophies: A propensity-matched nationwide analysis.

Background And Purpose: The literature lacks large studies on outcomes of cerebrovascular disease (CVD) in patients with muscular dystrophies (MDs). Previous studies primarily focused on ischemic stroke. CVD can add considerable morbidity in patients with MD.

Electrochemical reconstruction of metal-organic gels into crystalline oxy-hydroxide heterostructures for efficient oxygen evolution electrocatalysis.

Metal-organic gels (MOGs) are emerging soft materials with distinct metal active centers, multifunctional ligands and hierarchical porous structures, showing promising potential in the field of electrocatalysis. However, the reconfiguration of MOGs during the electrocatalytic process remains underexplored, with current studies in early developmental stages. To deeply investigate the application of MOG materials in electrocatalysis, the compositional transformations and structural changes under an electrochemical activation method were studied in detail, leading to high-performance OER pre-electrocatalysts.

Down-regulation of ESRP2 inhibits breast cancer cell proliferation via inhibiting cyclinD1.

Epithelial splicing regulatory protein 2 (ESRP2),an important alternative splicing protein of mRNA, is reported to have a dual role in tumors, which can promote or inhibit the occurrence and development of tumors. However, the function and mechanism of ESRP2 in breast cancer (BC) remain unclear. The distribution of ESRP2 expression in breast cancer and the correlation between ESRP2 expression and the overall survival rate were detected by The Cancer Genome Atlas (TCGA) database.

GPX4 Promoter Hypermethylation Induced by Ischemia/Reperfusion Injury Regulates Hepatocytic Ferroptosis.

Background And Aims: Glutathione peroxidase 4 (GPX4) is a key factor in ferroptosis, which is involved in ischemia-reperfusion injury. However, little is known about its role in hepatic ischemia-reperfusion injury (HIRI). This study aimed to investigate the role of GPX4 methylation in ferroptosis during HIRI.

Role of HDAC3 in the epithelial-mesenchymal transition of retinal pigment epithelium cells: Implications for proliferative vitreoretinopathy.

Proliferative vitreoretinopathy(PVR) is a type of fibrotic eye disease with a poor clinical prognosis. Increasing evidence has shown that the primary pathological mechanism of PVR is the epithelial-mesenchymal transition(EMT) of retinal pigment epithelium(RPE) cells. Histone deacetylase 3(HDAC3) is a crucial enzyme involved in regulating the acetylation level of proteins.

Predicting sarcopenia in community-dwelling older adults through comprehensive physical fitness tests.

Background: Sarcopenia is typically assessed through hand grip strength, walking speed, and chair stand tests. However, it has been inadequately examined in terms of other physical fitness (PF) components in community-dwelling older adults. Thus, in this study, we explored factors influencing the risk of sarcopenia in community-dwelling older adults.

Exosomal lncRNA Mir100hg derived from cancer stem cells enhance glycolysis and promote metastasis of melanoma through miR-16-5p and miR-23a-3p.

Increasing evidence demonstrate that the significant role of long non-coding RNA (lncRNA) in metastasis and the remodeling of the tumor microenvironment. However, the precise mechanisms of lncRNAs in cancer metastasis are still poorly understood. The function of lncRNA-Mir100hg in melanoma and its involvement in mediating communication between tumor stem cells and non-stemness tumor cells remains unknown.

Super broad and protective nanobodies against Sarbecoviruses including SARS-CoV-1 and the divergent SARS-CoV-2 subvariant KP.3.1.1.

The ongoing evolution and immune escape of SARS-CoV-2, alongside the potential threat of SARS-CoV-1 and other sarbecoviruses, underscore the urgent need for effective strategies against their infection and transmission. This study highlights the discovery of nanobodies from immunized alpacas, which demonstrate exceptionally broad and potent neutralizing capabilities against the recently emerged and more divergent SARS-CoV-2 Omicron subvariants including JD.1.