Carmiseconapine A as a Promising Antidepressant Candidate: An Adenosine 5'-Monophosphate-Activated Protein Kinase Agonist with an Unprecedented Chemical Skeleton.

A novel rearranged C-diterpenoid alkaloid, carmiseconapline A (), featuring a unique 10,20:11,12-di--napelline skeleton with a fused 5/6/5/6/7 pentacyclic ring system, was isolated from Debeaux. Compound exhibited remarkable antidepressive activity, being twice as potent as fluoxetine (10 mg/kg) at 0.06 mg/kg in mice.

Flexible microcolumn array-based silk fibroin for sweat glucose monitoring.

Flexible sweat sensors possess the special potential for continuous non-invasive monitoring of human blood glucose. We put forward a flexible microcolumn array sensor, which is designed for health monitoring by means of detecting glucose levels in sweat and capturing physiological signals related to human movement. With the combination of silk fibroin (SF), waterborne polyurethane (PU), and multi-walled carbon nanotubes (MWCNT), this microcolumn film electrode is able to effectively function as a strain sensor benefiting from the superior mechanical performance of PU.

Recanalization for Symptomatic Non-acute Intracranial Large Vessel Occlusion: An Observational Study.

Aim: This study investigated the efficacy and safety of endovascular revascularization for symptomatic non-acute atherosclerotic intracranial LVO.

Methods: For non-acute atherosclerotic intracranial large vessel occlusion (LVO), despite aggressive medical treatment, recurrent ischemic stroke or transient ischemic attack related to the occluded artery still occurs repeatedly. This retrospective cohort study included stroke patients with intracranial LVO who received endovascular treatment (EVT), categorized by successful recanalization and the time interval from symptom onset to revascularization (＜30 days vs.

Mechanisms of cognitive impairment associated with cerebral infarction.

Cerebral infarction is a common type of stroke with high incidence and disability rates, and most patients experience varying degrees of cognitive impairment. The manifestations and severity of post-infarction cognitive impairment are influenced by multiple interacting factors, and its pathophysiological mechanisms are highly complex, involving pericyte degeneration, excessive generation of reactive oxygen species (ROS), overproduction of glutamate, and overactivation of autophagy. After cerebral infarction, abnormal pericyte function activates neuroinflammation and facilitates the entry of inflammatory mediators into the brain; detachment of pericytes from blood vessels disrupts the integrity of the blood-brain barrier.

Impact of Enhanced Recovery After Surgery on Psychological Outcomes in Total Hip Arthroplasty.

Background: The occurrence of pain catastrophizing, depression, and anxiety is prevalent among patients undergoing primary total hip arthroplasty (THA). The Enhanced Recovery After Surgery protocol (ERAS-P) has demonstrated its efficacy in alleviating peri-operative stress responses in such patients. This study endeavors to explore the influence of ERAS-P on patient satisfaction, as well as the levels of pain catastrophizing, surgery-related anxiety, and depression following primary THA.

Dosimetry and Toxicity Comparison of Three-Dimensional Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy in Locally Advanced Lung Cancer Across a Large Statewide Quality Collaborative.

Purpose/objective(s): Use of intensity-modulated radiation therapy (IMRT) versus three-dimensional conformal external beam radiation therapy (3D-CRT) for definitive chemoradiation therapy (CRT) in locally advanced non-small cell lung cancer (LA-NSCLC) has been associated with decreased late pneumonitis, decreased high dose to the heart (itself associated with improved overall survival), and improved patient quality of life. In a statewide radiation oncology quality consortium, we sought to evaluate the impact of IMRT versus 3D-CRT treatment technique on dosimetry and toxicity.

Materials/methods: From 2012 to 2022, 1746 LA-NSCLC patients meeting inclusion criteria underwent definitive RT (90% CRT) with either 3D-CRT (n=313) or IMRT (n=1433) and were enrolled in the [quality consortium] prospective, multicenter statewide initiative.

12-month outcomes of pulsed-field ablation with a variable-diameter circular catheter for paroxysmal atrial fibrillation: Insights into conscious sedation and fluoroscopy use.

Background: Pulsed-field ablation (PFA) emerges as an innovative nonthermal energy modality for catheter ablation of atrial fibrillation (AF). This study aimed to assess the safety and effectiveness of a novel PFA system that uses a multichannel, circular ablation catheter with adjustable diameters in treating paroxysmal AF.

Methods: This clinical trial (PF-Beat-AF) was a prospective, multicenter, single-arm study.

20-Week Toxicity Study of Rotigotine Behenate Extended-Release Microspheres for Intramuscular Injection in Sprague Dawley Rats.

Based on the concept of continuous dopaminergic stimulation (CDS), Rotigotine Behenate extended-release microspheres for injection (RBEM) are currently under development. To support human clinical trials of RBEM, a 20-week repeat-dose toxicity study was conducted. SD rats intramuscularly received RBEM (60, 180, and 540 mg/kg) once every 4 weeks for 5 repeated doses followed by a 12-week recovery period, no clear sex difference was noted in the plasma exposure of rotigotine in rats, and the exposure generally increased in a dose-proportional manner.

Pre-enrichment-free electrochemical detection of lead ions using functionalized tungsten oxide: Integration of surface functionalization and redox cycling mechanisms.

Methods for electrochemical detection of heavy metal ions have garnered widespread attention due to their high sensitivity, ease of operation, low cost, and suitability for on-site detection. However, these methods typically require a pre-enrichment step to improve the detection limit and sensitivity, which increases operational complexity and introduces potential errors. In this study, tungsten oxide electrodes with various functional groups were prepared by electrodeposition and high-temperature annealing, utilizing the amphoteric properties of l-alanine.

An efficient circularly polarized luminescence probe base on anthryl-modified Eu(III)-helicates for the detection and imaging singlet oxygen in living cells.

Singlet oxygen (O) is the main active ingredient in photodynamic therapy (PDT). However, an excess O can cause unnecessary toxicity. Therefore, it is of great importance to develop reliable and sensitive methods or probes for detecting O in biological systems.

Environmental concentration of the quaternary ammonium disinfectant benzalkonium chloride strongly induces resistance gene profiles in fish.

Disinfectants are non-antibiotic biocides that have been used extensively in daily life, particularly since the onset of the COVID-19 pandemic. However, their effect on drug resistance has not received sufficient attention. Here, marine medaka were subjected to an environmental concentration (10 μg/L) of benzalkonium chloride (BAC), sulfamethazine (SMZ), and their combination, aiming to elucidate their contributions to antibiotic resistance.

Improving freeze-thaw stability of black carp (Mylopharyngodon piceus) fillets by light salting combined with vacuum packaging:Emphasis on oxidative and structural properties.

Effect of light salting and vacuum packaging on the quality characteristics of black carp fillets and its underlying mechanisms were studied under repeated freeze-thaw conditions. The content of frozen water decreased from 73.51% to 59.

Construction and application of coastal ecosystem model coupling multiple human activities.

The combined impact of multiple human activities is the primary driver of coastal ecosystem degradation, and comprehending its mechanisms is essential for developing adaptive management strategies. A coastal ecosystem model coupling multiple human activities, including runoff discharge, reclamation, mariculture, and atmospheric deposition, was developed using the Regional Ocean Modeling System (ROMS) coupled with the Carbon, Silicate, and Nitrogen Ecosystem (CoSiNE) model. The model performance was rigorously evaluated in the Bohai Sea as the study area.

Toward the enhancement of affective brain-computer interfaces using dependence within EEG series.

In recent years, electroencephalogram (EEG)-based emotion recognition technology has made remarkable advances. However, a subtle but crucial problem caused by the sliding window method has long been overlooked, which is the serious quantity mismatch between stimuli and short-term EEG frames. This may be an important factor limiting the performance of the emotion recognition systems.

Type A Aortic Dissection Following Abdominal Solid Organ Transplantation: Population-Level Outcomes in the United States.

Background: This study aims to analyze the patient characteristics, clinical outcomes, and contemporary trends concerning type A aortic dissection (TAAD) in previous recipients of abdominal solid organ transplantation (ASOT) in the United States.

Methods: The National Inpatient Sample was queried to identify all patients aged ≥18 with TAAD and a history of ASOT (TAAD-ASOT) between 2002 and 2015Q3 using ICD-9 diagnosis and procedure codes. Baseline characteristics and in-hospital outcomes were compared between TAAD-ASOT patients and TAAD patients without a history of ASOT (TAAD-non-ASOT).

Docetaxel-Loaded Electrospun Nanofibrous Mats for Local Chemotherapy Targeting Positive Surgical Margins in Prostate Cancer.

Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local chemotherapy drug delivery systems based on nanomaterials offer promising strategies to address this issue by modifying drug release kinetics and distribution, thereby enhancing antitumor effects while minimizing the toxicities associated with systemic chemotherapy. In this study, we utilized electrospun nanofibrous mats loaded with docetaxel for sustained drug delivery.

Copper-Catalyzed -Heteroannulation of [60]Fullerene with Aryl Sulfonamides and Paraformaldehyde: Synthesis and Functionalization of [60]Fullerene-Fused Imidazolidines.

The Cu(II)-catalyzed -heteroannulation reaction of [60]fullerene (C) with aryl sulfonamides and paraformaldehyde has been disclosed for the synthesis of diverse C-fused imidazolidines, of which one or both of the ArSO moieties could be removed selectively. Further transformations into the unexpected bicyclic 1,2,3,4-adduct and C-fused imidazolidinium iodide salt have also been demonstrated. A plausible reaction mechanism is proposed on the basis of control experiments.

Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models.

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade serous ovarian cancer with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within the tumor and microenvironment.

Cancer gene identification through integrating causal prompting large language model with omics data-driven causal inference.

Identifying genes causally linked to cancer from a multi-omics perspective is essential for understanding the mechanisms of cancer and improving therapeutic strategies. Traditional statistical and machine-learning methods that rely on generalized correlation approaches to identify cancer genes often produce redundant, biased predictions with limited interpretability, largely due to overlooking confounding factors, selection biases, and the nonlinear activation function in neural networks. In this study, we introduce a novel framework for identifying cancer genes across multiple omics domains, named ICGI (Integrative Causal Gene Identification), which leverages a large language model (LLM) prompted with causality contextual cues and prompts, in conjunction with data-driven causal feature selection.

The causal relationships between inflammatory cytokines, blood metabolites, and thyroid cancer: a two-step Mendelian randomization analysis.

Background: Thyroid cancer is a prevalent malignant tumor, especially with a higher incidence in women. Tumor microenvironment changes induced by inflammation and alterations in metabolic characteristics are critical in the development of thyroid cancer. Nevertheless, their causal relationships remain unclear.

New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka.

In recent years, multiple population outbreaks of the Northern Pacific starfish (Asterias amurensis) have been documented off the coast of Qingdao. Starfish use chemosensation to regulate their life history and interactions with the environment, with their secondary metabolites serving as deterrents and dispersal agents against predators. While the eggs of marine fish are passive and susceptible, we hypothesized that the secondary metabolites of A.

Disulfidptosis: a novel gene-based signature predicts prognosis and immunotherapy efficacy of pancreatic adenocarcinoma.

Disulfidptosis, a novel form of disulfide stress-induced cell death involved in tumor progression, hasn't be well defined the function in tumor progression. And the clinical impacts of disulfidptosis-related genes (DRGs) in pancreatic adenocarcinoma (PAAD) remain largely unclear. In this study, we identified two distinct disulfidptosis subtypes and found that multilayer DRG alterations were associated with prognosis and TME infiltration characteristics.

Atomistic insights into the humidity response of nanocellulose: a molecular dynamics study.

Context: TEMPO-oxidized cellulose nanofibers (TOCNFs) show significant potential for developing high-performance resistive humidity sensors due to their hydrophilicity and structural adaptability. However, the underlying atomic-scale mechanisms governing their humidity response remain poorly understood. Using molecular dynamics simulations, this study investigates how crystal facets, nanopore widths, and humidity levels influence the surface wettability, water permeability, and swelling of TOCNFs.

Effects of Pichia sp. J1 and Plant Growth-Promoting Bacterium on Enhancing Tobacco Growth and Suppressing Bacterial Wilt.

Tobacco bacterial wilt (TBW), caused by Ralstonia solanacearum, significantly impacts tobacco yield and quality, leading to substantial economic losses. This study investigated the effects of the microbial agents JX (Pichia sp. J1 and Klebsiella oxytoca ZS4) on the soil properties, rhizospheric microbial community, tobacco agronomic traits, and TBW incidence through field experiments.