Publications by authors named "Yutaro Yamagata"
Article Synopsis
- The study assessed the impact of trabeculectomy with mitomycin C (Trab MMC) on visual field progression in patients with glaucoma and high myopia.
- The research involved 35 eyes from 32 patients who had undergone Trab MMC, showing a significant reduction in intraocular pressure (IOP) post-surgery across both high myopic and non-highly myopic groups.
- While IOP decreased and visual field deterioration slowed in both groups, the improvement was more pronounced in the non-highly myopic group compared to the highly myopic group, where the changes were not statistically significant.
The site2protease (S2P) family of intramembrane proteases (IMPs) is conserved in all kingdoms of life and cleaves transmembrane proteins within the membrane to regulate and maintain various cellular activities. RseP, an S2P peptidase, is involved in the regulation of gene expression through the regulated cleavage of the two target membrane proteins (RseA and FecR) and in membrane quality control through the proteolytic elimination of remnant signal peptides. RseP is expected to have additional substrates and to be involved in other cellular processes.
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- Defective interfering (DI) influenza viruses have a substantial gene deletion that prevents them from replicating on their own but could be useful for antiviral therapies.
- Researchers created a stable clonal DI virus using reverse genetics and a specialized cell line to ensure it doesn't require a helper virus for replication.
- This new method not only helps produce pure clonal DI viruses for further study but also aids in understanding how they interfere with typical virus replication, paving the way for potential antiviral treatments.
In the present study, we demonstrate single-molecule imaging of triple helix formation in DNA nanostructures. The binding of the single-molecule third strand to double-stranded DNA in a DNA origami frame was examined using two different types of triplet base pairs. The target DNA strand and the third strand were incorporated into the DNA frame, and the binding of the third strand was controlled by the formation of Watson-Crick base pairing.
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