Publications by authors named "Yutaka Hanaoka"

Article Synopsis
  • BRAF V600E mutation-positive advanced recurrent colorectal cancer has a poor prognosis, leading to the approval of encorafenib, binimetinib, and cetuximab in Japan in 2020 for treatment.
  • A patient treated with these drugs developed grade 3 pancreatitis, leading to a dose reduction of encorafenib and binimetinib before resuming treatment successfully.
  • Despite the rare occurrence of pancreatitis with these medications, the adjusted regimen is deemed suitable for long-term management in older patients with this type of cancer.
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Unlabelled: Although recent methods of pelvic reconstruction using myocutaneous flaps have reduced postoperative morbidities' including pelvic abscess, the complication rates are still high due to the presence of a large dead cavity and poorly vascularized tissues secondary to preoperative chemoradiation therapy. We aimed to evaluate the usefulness and benefit of fascia lata autografting for pelvic floor reconstruction as a supplemental procedure for gluteal flap closure of perineal wounds.

Methods: Our retrospective study included 144 consecutive patients who underwent rectal cancer resection with or without pelvic reconstruction, from 2010 to 2020.

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The aim of this study was to clarify the clinical impact of inferior mesenteric lymph node (IMLN) metastasis from cancer of the sigmoid colon or rectum. A total of 952 patients underwent curative surgery with IMLN dissection for either sigmoid colon cancer or rectal cancer from January 2000 to August 2018. Of these, 26 (2.

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Background: Preoperative nutritional status is reportedly associated with the clinical outcomes in patients with colorectal cancer (CRC), although it remains inconclusive whether the preoperative nutritional status that may improve after surgery is truly predictive of the survival outcomes of patients with CRC.

Methods: Clinical records of patients with stage III CRC (n = 821) in whom curative resection had been achieved were retrospectively reviewed and the prognostic impact of nutritional status, determined by the controlling nutritional status (CONUT) score, was analyzed.

Results: The CONUT undernutrition grade was significantly associated with the overall survival rate (OS) in the original population (P < 0.

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Article Synopsis
  • The study investigated the safety of laparoscopic surgery for colorectal cancer (CRC) in patients with pulmonary dysfunction and identified risk factors for post-operative complications.
  • Out of 213 patients analyzed, 18.8% experienced complications, with low forced expiratory volume (FEV1.0) and percentage vital capacity (%VC) being significant risk factors.
  • The findings highlighted that both low FEV1.0 and low %VC are critical indicators of the likelihood of post-operative complications after laparoscopic surgery for CRC.
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  • Advanced low rectal cancer carries a risk of lateral pelvic lymph node metastasis (LPLNM) and local recurrence, and while LPLN dissection can reduce recurrence, it may lead to postoperative complications.
  • This study aimed to create a radiomics-based prediction model to better assess the risk of LPLNM in rectal cancer patients undergoing neoadjuvant treatment.
  • The model showed improved accuracy over traditional methods, demonstrating better discrimination in both the primary and validation cohorts, suggesting that radiomics analysis can enhance personalized risk assessment in this patient population.
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Background: Ischemic colitis can occur after colectomy and is sometimes difficult to treat. We report 4 cases of refractory, delayed onset, regional congestive colitis occurring on the anal side of the anastomosis after laparoscopic left hemicolectomy.

Case Presentation: A total of 191 patients underwent surgery for left colon cancer (transverse, descending, and sigmoid colon cancer) at our hospital from January 2012 to December 2017.

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Article Synopsis
  • Colonic diverticular disease is becoming more common, particularly in older populations in Western countries and Japan, leading to challenging surgeries for related complications like colovesical fistulas.
  • A retrospective review of 39 patients who underwent standardized laparoscopic surgery revealed a median age of 60 and successful outcomes, with no major complications or conversions to open surgery.
  • This study highlights the effectiveness of laparoscopic procedures in treating colovesical fistulas, marking it as the largest analysis of this technique to date.
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Article Synopsis
  • Myxoglobulosis is a specific type of appendiceal mucinous neoplasm that can arise due to factors like obstruction, mucosal secretion, and chronic inflammation, particularly after incidents like perforated barium appendicitis.
  • A 45-year-old man's case showed that after undergoing surgery for an appendiceal issue related to prior barium exposure, he was diagnosed with low-grade appendiceal mucinous neoplasm and myxoglobulosis, linked to prolonged inflammation.
  • The findings highlight the risks associated with barium peritonitis, including strong adhesions making surgical procedures more complicated, necessitating cautious surgical techniques to prevent further complications.
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Laparoscopic surgery for rectal cancer offers favorable short-term results without compromising long term oncological outcomes so far, according to the data from major trials. For this reason, it is currently considered as a standard option for rectal cancer surgery. The learning curve of laparoscopic rectal cancer surgery is generally longer compared to colon cancer.

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Background: The local recurrence of rectal cancer classifies 4 types, anterior, posterior, lateral compartment and anastomotic site. This study evaluates outcome of laparoscopic lateral lymph node dissection(LLND)against the lateral lymph node recurrence.

Method: Five patients were diagnosed as the lateral lymph node recurrence and underwent laparoscopic LLND.

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We present a case of bilateral lymph node metastases of rectal cancer treated with chemotherapy and surgery. The patient was a 65-year-old man with upper rectal cancer. Laparoscopic low anterior resection(LAR)was performed.

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Background: The use of laparoscopic surgery for colorectal cancer has become widespread recently. However, the safety and oncological outcomes of laparoscopic surgery for primary advanced colorectal cancer need extensive investigation. We analyzed the short- and long-term outcomes after laparoscopic multivisceral resection for primary colon cancer with suspected invasion of other organs at a single institution.

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The programmed death-1/programmed death-ligand 1 (PD-L1) pathway is a negative feedback pathway that suppresses the activity of T cells. Previous studies reported that high PD-L1 expression on tumor cells (TC) was associated with poor survival in patients with colorectal cancer; however, the prognostic evaluation of these studies was limited because they included patients at various disease stages. The purpose of the present study was to evaluate the relationship between PD-L1 status in the immune microenvironment and the clinicopathological features of stage III colorectal cancer.

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Background: As laparoscopic surgery has become the mainstream technique for abdominal surgery, it has become difficult for surgical residents to have opportunities to perform open surgery. This study aimed to examine the appropriateness and feasibility of laparoscopic appendectomy performed by surgical trainees who had little experience with open appendectomy or laparoscopic training with animal models.

Methods: We retrospectively reviewed all the records of patients who underwent appendectomy for acute appendicitis from April 2008 to December 2014.

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Introduction: FOLFOX and panitumumab combined chemotherapy plays an important role for metastatic colorectal cancer. However the usefulness of this regimen for neoadjuvant therapy is unclear.

Case Report: A 67-year-old man with abdominal pain and pneumaturia was diagnosed with RAS wild-type sigmoid colon cancer with urinary bladder invasion and colovesical fistulas.

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Article Synopsis
  • * Despite initial conservative treatments, a significant chylous fistula persisted until postoperative day 120, prompting further examination with percutaneous lymphangiography to locate the leak.
  • * The patient underwent laparoscopic surgery to ligate the leakage point found at the previous lymphadenectomy site, successfully stopping the fluid leakage, and he was discharged two weeks later without any recurrence.
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Hepatitis C virus (HCV) infection is one of the most common blood-borne infections worldwide. Little is known with respect to changes in HCV status during chemotherapy for colorectal cancer (CRC), and the influence of HCV infection on chemotherapy remains unclear. Between 2001 and 2012, 3,260 patients were diagnosed with CRC in our institute.

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Anastomotic stricture reportedly often recurs following barium peritonitis, regardless of whether the anastomotic diameter is initially sufficient. However, the causes of repetitive stricture have not been clarified. We report a case that suggests the pathophysiology of recurrent anastomotic strictures following barium peritonitis.

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Objective: To perform a retrospective analysis of UFT and oral leucovorin combination adjuvant chemotherapy for Stage III colon cancer patients over 76 years old, in order to evaluate both treatment efficacy and toxicity.

Subjects: Between 2002 and 2011, 333 Stage III colon cancer patients had surgery performed in our institute, and we studied 25 of them on our chemotherapy regimen.

Results: Patients'median age was 78 years old, with 12 men and 13 women.

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Objective: To perform a retrospective analysis of UFT and oral leucovorin plus PSK combination adjuvant chemotherapy for stage III colon cancer in order to evaluate both treatment efficacy and toxicity.

Subjects: Between 2003 and 2009, 273 stage III colon cancer patients underwent surgery in our institute, and we studied 156 of them.

Results: Patients' median age was 72 years old; 87 men and 69 women.

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