Publications by authors named "Yutai Zhao"
Article Synopsis
- Polycystic ovary syndrome (PCOS) affects 8-13% of women in their reproductive years and is commonly treated with off-label drugs that can have side effects; this study investigates curcumin's therapeutic effects in a PCOS rat model.
- The PCOS model was created using dehydroepiandrosterone (DHEA), followed by curcumin treatment, which assessed changes in ovarian morphology, hormone levels, and oxidative stress markers.
- Results showed that curcumin improved hormone levels, restored normal ovarian function, and reduced oxidative stress, suggesting its potential as a treatment for PCOS by enhancing PPAR-γ levels.
Objective: Hec1 is a component of the Ndc80 kinetochore complex and is frequently upregulated in various cancers. However, the clinical significance of Hec1 in cervical cancer remains largely unknown. This study aimed to investigate the expression patterns of Hec1 in cervical cancer and its relationship with the clinicopathological characteristics of patients diagnosed with the disease.
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- This study investigates the role of ATG7, a protein involved in autophagy, in women with and without polycystic ovary syndrome (PCOS).
- It found that women with PCOS had significantly lower serum ATG7 levels compared to healthy women, which indicates an increased risk of developing the condition.
- The research suggests that ATG7 could be a potential biomarker for diagnosing and managing PCOS, especially in combination with HOMA-IR measurements.