Publications by authors named "Yuta Tozawa"
Amyloid polypeptide aggregation is considered one of the factors involved in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), and the number of affected patients increases as the population ages. Amyloid β (Aβ) found in the brain of patients with AD and human islet amyloid polypeptide (hIAPP) found in the pancreas of patients with T2D are thought to be cytotoxic during the aggregation process, especially the low-molecular-weight oligomers that are aggregation intermediates. In this study, meroterpenoids isolated and structurally determined from the brown alga Sargassum macrocarpum were evaluated for their ability to inhibit hIAPP aggregation.
View Article and Find Full Text PDFArticle Synopsis
- Researchers are exploring ways to prevent and treat Alzheimer's by inhibiting the aggregation of amyloid β (Aβ) proteins.
- They discovered seven new compounds called sargasilides from a type of brown algae in Japan and studied their effects on Aβ aggregation.
- Sargasilide B showed the most promising results, with structural features like olefin arrangement and side chain length affecting the compounds' effectiveness.
Amyloid β (Aβ) is thought to be involved in the pathogenesis of Alzheimer's disease (AD). Aβ aggregation in the brain is considered the cause of AD. Therefore, inhibiting Aβ aggregation and degrading existing Aβ aggregates is a promising approach for the treatment and prevention of the disease.
View Article and Find Full Text PDF