Publications by authors named "Yuta Ouchi"
Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes.
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- Methamphetamine (METH) and phencyclidine (PCP) have different pharmacological effects but can lead to similar psychiatric disorders like abuse and psychosis, resembling schizophrenia.
- Brain damage and changes in gene expression contribute to these mental disorders, prompting researchers to study the genetic alterations using serial analysis of gene expression (SAGE).
- Analysis of cerebral cortices from treated rats revealed both upregulated and downregulated genes related to METH and PCP, indicating shared molecular pathways in their psychiatric effects.