Publications by authors named "Yuta Katai"
Article Synopsis
- Mutations in the LRRK2 gene are linked to familial Parkinson's disease, with recent research highlighting its role in phosphorylating Rab family proteins like Rab12, which may impact disease development.
- In experiments, overexpression of pathogenic LRRK2 caused lysosomes to cluster near the cell nucleus, dependent on the kinase's activity and requiring Rab12 and its effector RILPL1.
- The study concluded that increased phosphorylation of Rab12 by mutated LRRK2 disrupts normal lysosomal transport, suggesting a mechanism for how LRRK2 mutations contribute to Parkinson's disease pathology.*
