Publications by authors named "Yuta Horie"
Article Synopsis
- Oryzamutaic acids, which come from a rice mutant and have a unique nitrogen-containing structure, are believed to have beneficial properties but are hard to study due to their variety and low concentrations.
- The study developed an easy lab method to produce these acids using an enzyme called L-lysine ε-dehydrogenase (LysDH) from Agrobacterium tumefaciens, which was first cloned and expressed in E. coli.
- The researchers successfully created 1.6 mg of oryzamutaic acid H from 100 mg of L-lysine, discovering that it has UVA absorption and remains stable across different temperatures and pH levels, making it the first report of its enzymatic synthesis
Article Synopsis
- Definitive chemoradiotherapy (dCRT) with docetaxel, cisplatin, and 5-fluorouracil (DCF-RT) is a promising first-line treatment for advanced cervical esophageal squamous cell carcinoma (ESCC), aimed at preserving the larynx.
- In a study of 18 patients, the treatment achieved a complete response (CR) in 15 individuals, but 7 of those experienced recurrence, while 2 had stable disease and 1 progressive disease.
- The 3-year survival rates were reported as 44.2% overall, with 47.7% disease-free and 48.6% disease-specific, suggesting that while the treatment shows potential,
The Keap1-Nrf2 system is central for mammalian cytoprotection against various stresses and a drug target for disease prevention and treatment. One model for the molecular mechanisms leading to Nrf2 activation is the Hinge-Latch model, where the DLGex-binding motif of Nrf2 dissociates from Keap1 as a latch, while the ETGE motif remains attached to Keap1 as a hinge. To overcome the technical difficulties in examining the binding status of the two motifs during protein-protein interaction (PPI) simultaneously, we utilized NMR spectroscopy titration experiments.
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