Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia.

The prevalence of myopia has been steadily increasing for several decades, and this condition can cause extensive medical and economic issues in society. Exposure to violet light (VL), a short wavelength (360-400 nm) of visible light from sunlight, has been suggested as an effective preventive and suppressive treatments for the development and progression of myopia. However, the clinical application of VL remains unclear.

Human Flow Dataset Reveals Changes in Citizens' Outing Behaviors including Greenspace Visits before and during the First Wave of the COVID-19 Pandemic in Kanazawa, Japan.

Greenspaces, including parks, provide various socio-ecological benefits such as for aesthetics, temperature remediation, biodiversity conservation, and outdoor recreation. The health benefits of urban greenspaces have received particular attention since the onset of the COVID-19 pandemic, which has triggered various movement restrictions and lifestyle changes, including regarding the frequency of people's visits to greenspaces. Using mobile-tracking GPS data of Kanazawa citizens, we explored how citizens' behaviors with respect to outings changed before and during Japan's declaration of a COVID-19 state of emergency (April-May 2020).

Intensified East Asian winter monsoon during the last geomagnetic reversal transition.

The strength of Earth's magnetic dipole field controls galactic cosmic ray (GCR) flux, and GCR-induced cloud formation can affect climate. Here, we provide the first evidence of the GCR-induced cloud effect on the East-Asian monsoon during the last geomagnetic reversal transition. Bicentennial-resolution monsoon records from the Chinese Loess Plateau revealed that the summer monsoon (SM) was affected by millennial-scale climate events that occurred before and after the reversal, and that the winter monsoon (WM) intensified independently of SM variations; dust accumulation rates increased, coinciding with a cooling event in Osaka Bay.

Quantitative prediction of ionization effect on human skin permeability.

Although skin permeability of an active ingredient can be severely affected by its ionization in a dose solution, most of the existing prediction models cannot predict such impacts. To provide reliable predictors, we curated a novel large dataset of in vitro human skin permeability coefficients for 322 entries comprising chemically diverse permeants whose ionization fractions can be calculated. Subsequently, we generated thousands of computational descriptors, including LogD (octanol-water distribution coefficient at a specific pH), and analyzed the dataset using nonlinear support vector regression (SVR) and Gaussian process regression (GPR) combined with greedy descriptor selection.

Evaluation of the suppressive effect on bitter taste of gluconate.

Gluconate is used as an additive in a wide range of processed foods. In this study, we investigated its utility as a taste-improving substance. To determine whether it has a suppressive effect on bitter taste, sensory evaluations were performed by human subjects.

Involvement of specific transport system on uptake of lactone form of SN-38 in human intestinal epithelial cell line Caco-2.

The aim of this study was to elucidate the characteristics of the transport of lactone and carboxylate forms of SN-38 (SN-38L and SN-38C, respectively), a metabolite of irinotecan hydrochloride (CPT-11), with the human intestinal epithelial cell line, Caco-2. We examined SN-38L and SN-38C uptake from the apical side into Caco-2, and the effects of various compounds on the uptake of SN-38L. SN-38L and SN-38C in the cells were determined by HPLC with a fluorescence detector.