Publications by authors named "Yusuke Takase"
Article Synopsis
- Veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a serious complication that can occur after hematopoietic cell transplantation (HCT), especially in pediatric patients.
- A study at Kyushu University Hospital evaluated the effects of early defibrotide (DF) therapy on children with VOD/SOS after HCT, revealing that VOD/SOS was more common in patients treated post-DF introduction, likely due to higher cases of relapsed/refactory acute lymphoblastic leukemia (ALL).
- Findings suggest that starting DF therapy early based on specific diagnostic criteria significantly lessens the severity of VOD/SOS and improves survival, although the overall incidence of VOD/SOS
Article Synopsis
- Differentiation therapy shows potential for treating acute myeloid leukemia (AML), but effective methods that work across different AML subtypes are needed.
- The study reveals that inhibiting a specific regulatory element of FOXO genes can induce differentiation in AML cells, identifying TRIB1 as a key gene that keeps these cells undifferentiated.
- A new therapeutic approach combining a DNA-binding inhibitor with a chemotherapy drug effectively reduced TRIB1 levels, leading to AML cell differentiation and inhibiting tumor growth in animal models without significant side effects.
B-cell expansion with NF-κB (nuclear factor-kappa B) and T-cell anergy (BENTA) is a rare congenital lymphoproliferative disorder caused by germline gain-of-function mutations in the CARD11 gene. We herein report a familial case of BENTA due to a G123D heterozygous missense mutation in CARD11 inherited by a male from his mother. The mother's clinical course was characterized by polyarthritis and encephalitis in young adulthood, suggesting that autoimmune-like manifestations can occur in BENTA.
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- - Autophagy is important for maintaining healthy tissue stem cells, particularly in how it affects haematopoietic stem cells (HSCs) throughout different life stages, though its specific roles in HSC self-renewal are not well understood.
- - A study found that deleting Atg5, a gene critical for autophagy, had no immediate negative effects on HSCs at birth but caused significant issues by week 7, indicating that Atg5 is crucial for HSC function during early development.
- - The research highlights that Atg5's role in protecting HSCs during the neonatal period is vital for ensuring proper blood cell production in adulthood, and that its loss leads to increased oxidative stress and dysfunction in
Autophagy plays a critical role in tumorigenesis, but how autophagy contributes to cancer cells' responses to chemotherapeutics remains controversial. To investigate the roles of autophagy in malignant gliomas, we used CRISPR/CAS9 to knock out the ATG5 gene, which is essential for autophagosome formation, in tumor cells derived from patients with glioblastoma. While ATG5 disruption inhibited autophagy, it did not change the phenotypes of glioma cells and did not alter their sensitivity to temozolomide, an agent used for glioblastoma patient therapy.
View Article and Find Full Text PDFThe mammalian target of rapamycin (mTOR) complex 1 (mTORC1) senses a cell's energy status and environmental levels of nutrients and growth factors. In response, mTORC1 mediates signaling that controls protein translation and cellular metabolism. Although mTORC1 plays a critical role in hematopoiesis, it remains unclear which upstream stimuli regulate mTORC1 activity in the context of hematopoietic stem cells (HSC) maintenance in vivo.
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