Statistical model of trajectories of reduced mobility in older people with locomotive disorders: a prospective cohort study with group-based trajectory model.

Background: Today we experience "Super-aged society", and a drastic increase in the number of older people needing assistance is an urgent matter for everyone from medical and socio-economical standpoints. Locomotive organ dysfunction due to musculoskeletal disorders is one of the main problems in these patients. Although the concepts of frailty and sarcopenia have been proposed for functional decline, pain remains the main and non-negligible complaint in these of such disorders.

[Eight cases of calcific retropharyngeal tendinitis/retropharyngeal calcific tendinitis].

Calcific retropharyngeal tendinitis/retropharyngeal calcific tendinitis is an inflammation of the longus colli muscle caused by calcium hydroxyapatite crystal depositon in the longus colli muscle tendon. The three major symptoms are neck pain, limitations of neck movement, and swallowing pain. We treated 8 cases of calcific retropharyngeal tendinitis/ retropharyngeal calcific tendinitis.

[Re-treatment with epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI)for lung adenocarcinoma].

Background: EGFR-TKI yields a long survival period in cases of non-small cell lung cancer (NSCLC), especially those with EGFR gene mutations, but the effect is limited. The later treatment strategy is still a large problem. Efficacy by re-treatment with EGFR-TKI is sometimes reported, but its clinical significance is not clear.

[Treatment of malignant pericardial effusion].

Cardiac tamponade is an emergency situation that warrants immediate evacuation of the pericardial fluid. Since the fluid tends to recur only by pericardiocentesis, various agents have been instilled into the pericardium to promote adhesion and obliteration of the cavity. Comparative studies of sclerosing agents for the management of malignant pericardial effusion include that comparing the Bleomycin group and non-administered group (JCOG) and another comparing bleomycin and doxycycline in 1996.