Publications by authors named "Yusuke Mizunoue"
Structure and biosynthesis of the ribosomal lipopeptide antibiotic albopeptins.
Biosci Biotechnol Biochem
May 2022
Article Synopsis
- Albopeptins, discovered from Streptomyces albofaciens in 1986, are effective antibiotics against plant diseases but pose challenges in determining their chemical structures due to unusual properties.
- This study outlines the structural elucidation of albopeptin B, starting from a unique C13-fatty acid and constructing its octapeptide core using advanced NMR techniques.
- Additionally, MS/MS data confirmed the structure of other albopeptin members and suggested a biosynthetic pathway akin to that of long-chain fatty acid lanthipeptides.