Publications by authors named "Yusuke Ishibashi"
We investigated the drug resistance status of Pseudomonas aeruginosa (P. aeruginosa) focusing on its isolation sites and types of diseases. Materials and methods: A microbiological laboratory database was searched to identify all clinical cultures positive for P.
View Article and Find Full Text PDFPeriostin (POSTN) is a matricellular protein that was originally identified in osteoblasts. Past studies have shown that POSTN is also preferentially expressed in cancer-associated fibroblasts (CAFs) in various types of cancer. We previously demonstrated that the increased expression of POSTN in stromal tissues is associated with an unfavorable clinical outcome in esophageal squamous cell carcinoma (ESCC) patients.
View Article and Find Full Text PDFBackground/aim: This study aimed to evaluate the prognostic value of modified geriatric nutritional risk index (mGNRI) in patients with unresectable/recurrent esophageal cancer (EC).
Patients And Methods: We included 143 patients aged >65 years with unresectable/recurrent EC. The mGNRI was calculated as (1.
Background: Postoperative subcutaneous emphysema (SE) is a possible complication of thoracoscopic or laparoscopic surgery. This study investigated the risk factors and clinical significance of SE after video-assisted thoracoscopic surgery for esophageal cancer (VATS-e).
Methods: This study included 135 patients who underwent VATS-e with artificial CO pneumothorax.
The aim of this cross-sectional study was to determine the status of locomotive syndrome (LS) and the level of physical activity (PA) in long-term inpatients in a psychiatric care ward and to investigate the association between the severity of LS and the level of PA. The study participants consisted of 25 patients aged 55 years or older who had been admitted to a psychiatric care ward for more than one year. The participants' LS stage was determined and their level of PA was measured using an accelerometer.
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- - This study aimed to explore the effects of physiotherapy on patients in psychiatric long-term care in Japan, specifically focusing on those who were discharged to the community versus those who remained hospitalized.
- - It involved 50 patients across four hospitals, documenting their demographics, diagnosis classifications, and physiotherapy duration, using the Functional Independence Measure (FIM) to assess progress.
- - Results indicated that 14 patients were discharged while 36 remained hospitalized, with notable differences in diagnosis types and length of stay; the discharged group also started with higher FIM scores and showed greater improvement.
Article Synopsis
- The study aimed to assess the tolerability of neoadjuvant chemotherapy (NAC) in elderly patients (≥ 76 years) with esophageal cancer, as previous trials excluded this age group despite showing survival benefits.
- Out of 174 patients, those aged 76 and older (E group) received NAC less frequently and had a lower completion rate compared to younger patients (Y group), along with lower relative dose intensity (RDI) of the chemotherapy drugs used.
- Elderly patients experienced more severe adverse events, particularly neutropenia, suggesting they may be more sensitive to the toxic effects of NAC, indicating the need for careful case selection and potential dose adjustments for this demographic.
Objectives: To evaluate the effect of 6-cycle completion and earlier use of radium-233 dichloride (Ra223) on the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC).
Methods: We retrospectively evaluated 75 patients with bone metastases-predominant mCRPC who were treated with Ra223 between August 2016 and August 2021. The primary purpose of the study was to assess the effect of Ra223 completion (6 cycles) on patient prognosis, and the secondary purpose was to investigate factors associated with Ra223 incompletion (fewer than 6 cycles) and overall survival.
The current study investigated the impact of preoperative fall risk assessment score (FRAS) on long-term prognoses in patients with esophageal cancer (EC). A total of 161 patients with EC who underwent curative surgery were classified into a high-risk (95, 41.0%) and low-risk (66, 41.
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- The COVID-19 pandemic led to changes in infection control practices, particularly in patients undergoing gastrointestinal surgeries for cancer.
- A study showed that during the pandemic, patients used hand sanitizer more frequently (14.9 times/day) compared to before (9.6 times/day), which correlated with a decrease in postoperative infections.
- Additionally, patients in the pandemic group had shorter hospital stays and there was a notable reduction in certain bacteria in microbiological cultures compared to before the pandemic.
The expression of mesothelin correlates with a poor prognosis in patients with breast cancer. Since mesothelin plays a role in cancer metastasis in association with CA125, we herein examined the expression of mesothelin and CA125, and the clinicopathological meaning and prognosis of the co-expression of mesothelin and CA125 in breast cancer. Our results showed that among 478 patients, mesothelin and CA125 were co-expressed in 48 (10 %), mesothelin only in 75 (16 %), CA125 only in 217 (45 %), and neither in 234 (49 %).
View Article and Find Full Text PDFBackground: Serum and tissue human epidermal growth factor receptor 2 (HER2) levels were evaluated in resected esophageal squamous cell carcinoma (SCC) specimens to assess the relationship between HER2 expression and long-term prognosis.
Methods: We included 95 patients who underwent esophagectomy for esophageal SCC. The serum HER2-extracellular domain (sHER2-ECD) levels were measured using an ELISA kit.
Platelet-related measures are considered important in predicting long-term outcomes in patients with esophageal squamous cell carcinoma (ESCC). We performed a systematic electronic research of studies evaluating the prognostic value of platelet-related measures in ESCC in Google Scholar, PubMed, Cochrane Library, and Embase. Then, to synthesize publications exploring the association between platelet-related measures and survival outcomes in ESCC, a meta-analysis was conducted using hazard ratio and 95 % confidence interval.
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- The study aimed to explore factors influencing the discharge of walkable patients from psychiatric long-term care facilities in Japan.
- Researchers assessed 73 walkable patients over two years, noting key differences in age, length of stay, and physical test scores between those discharged and those who remained hospitalized.
- The analysis found that age significantly predicts the likelihood of discharge, as it relates to both the decline in motor function and the availability of social support post-discharge.
Background: Patients in psychiatric care wards face serious problems in terms of declining physical function due to aging and long-term hospitalization. This study aimed to determine the current status of locomotive syndrome (LS) in long-term inpatients in psychiatric care wards and to clarify the factors associated with LS risk severity.
Methods: The study included 84 patients admitted to psychiatric care wards who underwent the LS stage test.
Objective: We focused on locomotive syndrome as a low physical function factor that may prevent patients with psychiatric disease from being discharged. The purpose of this study is to clarify the factors, including locomotive syndrome, that prevent discharge from psychiatric long-term care wards.
Method: We enrolled 74 patients who were admitted to psychiatric long-term care wards at three different hospitals in Japan.
Article Synopsis
- * The procedure involved creating artificial pneumothorax and careful dissection while preserving critical blood vessels, with the left-side operation taking 54 minutes and resulting in minimal blood loss.
- * No cancer recurrence was observed 24 months post-surgery, highlighting the safety and effectiveness of this minimally invasive approach for esophageal cancer patients with isolated lymph node metastasis.
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- The study examined how laparoscopic gastrectomy (LG) influences long-term survival for gastric cancer patients, especially those dealing with postoperative infectious complications (PIC).
- 608 patients were divided into two groups: those who had LG (385 patients) and those who had open gastrectomy (OG: 211 patients), then survival outcomes were compared based on the presence of PIC.
- Results showed that while PIC worsened survival outcomes in OG patients, it did not significantly affect the overall survival in LG patients, indicating that LG might have a better prognosis despite complications.
Objective: Falls are related to frailty, which is known as an unfavorable prognosticator of gastric cancer. In this study, we investigated the influence of the fall risk assessment score on short- and long-term prognoses in patients with gastric cancer after gastrectomy.
Methods: A total of 430 patients who underwent gastrectomy for gastric cancer were included in this retrospective study.
Background: The aim of this study was to investigate the impact of postoperative infectious complications on adjuvant chemotherapy administration in patients with gastric cancer.
Methods: A retrospective review of 308 patients who underwent curative resection for gastric cancer was performed. Patients were divided into two groups based on the presence (90 patients, 29.
Little is known about the association between sarcopenia development after gastrectomy and gastric cancer prognosis after recurrence. The present study retrospectively examined the effects of decreased psoas muscle index (PMI) on post-recurrence prognosis after gastrectomy. A total of 67 patients with gastric cancer recurrence were included in the present study.
View Article and Find Full Text PDFBackground: This study aimed to establish a simple and useful prognostic indicator for elderly esophageal cancer patients. We designed the modified geriatric nutrition risk index (mGNRI) using the inverse of C-reactive protein (CRP) instead of albumin and compared its prognostic value with those of the GNRI and other indices.
Methods: We included 128 patients aged > 65 years who underwent esophagectomy for esophageal cancer.
Article Synopsis
- - The study aimed to create a new systemic inflammatory score (SIS) using ratios like neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and C-reactive protein/albumin ratio (CAR) to predict outcomes for patients undergoing esophageal cancer surgery.
- - Involving 102 patients, it found that a higher SIS (2-3) correlated with poorer survival compared to a lower SIS (0-1), with SIS showing the best prognostic power among the measures tested (AUROC of 0.732).
- - Additionally, the high-SIS group showed significant relationships with specific cytokine levels, such as lower IL-6 and higher IL-10
Mesothelin is expressed in various types of malignant tumors. The present study immunohistochemically investigated mesothelin expression and its clinicopathological significance in each subtype of breast cancer, with special reference to its cellular localization, in particular, membrane mesothelin expression. Using tissue specimens from 482 patients with breast cancer, immunohistochemistry was used to study mesothelin expression and help classify its localization as membrane or cytoplasmic expression.
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- A retrospective study was conducted to analyze how postoperative pneumonia affects skeletal muscle loss in patients who underwent esophagectomy for esophageal cancer.
- The study included 123 patients, comparing those with pneumonia (30) to those without (93), and assessed muscle volume loss and survival rates over a 6-month period.
- Results showed that patients with pneumonia experienced a significant decrease in muscle volume and worse overall survival compared to those without pneumonia, along with a higher occurrence of asymptomatic pneumonia.