Publications by authors named "Yusuff H"
Right ventricular injury (RVI) in respiratory failure receiving veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with significant mortality. A scoping review is necessary to map the current literature and guide future research regarding the definition and management of RVI in patients receiving VV ECMO. We searched for relevant publications on RVI in patients receiving VV ECMO in Medline, EMBASE, and Web of Science.
View Article and Find Full Text PDFPersonalizing Permissive Hypercapnia in Acute Severe Respiratory Failure.
J Cardiothorac Vasc Anesth
December 2024
Purposes: This research highlights the need for affordable phantoms for MRI education. Current options are either expensive or limited. A phantom, easy to manufacture and distribute, is proposed to demonstrate various pedagogical concepts, aiding students in understanding MRI image quality concepts.
View Article and Find Full Text PDFIntroduction: Tissue-mimicking materials (TMMs) are now essential reference objects for quality control, development and training in all medical imaging modalities. This review aims to provide a comprehensive synthesis of materials used in the fabrication of TMMs for MRI phantoms, focusing on their composition, fabrication methods, and relaxation properties (T1 and T2).
Methods: A systematic review was conducted, covering articles published between 1980 and 2023.
To investigate epidemiology of and risk factors for laboratory-confirmed mpox during the 2022 outbreak in Nigeria, we enrolled 265 persons with suspected mpox. A total of 163 (61.5%) were confirmed to have mpox; 137 (84.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on veno-venous extracorporeal membrane oxygenation (VV-ECMO) for patients with severe respiratory failure, highlighting the significant impact of right ventricular injury (RVI) on patient outcomes amid the lack of a standard RVI definition and management strategies.
- - An international panel of experts, using a Delphi process, identified key areas of uncertainty about RVI and formulated expert position statements, achieving consensus on 31 out of 35 statements regarding nomenclature, diagnostic approaches, and management strategies related to RVI in the context of VV-ECMO.
- - While recommendations for RVI management were made, there was no consensus on specific strategies, such as RV-protective driving pressure thresholds
Background: Invasive pulmonary aspergillosis is a complication of severe COVID-19, with regional variation in reported incidence and mortality. We describe the incidence, risk factors and mortality associated with COVID-19-associated pulmonary aspergillosis (CAPA) in a prospective, multicentre UK cohort.
Methods: From March 2020 to March 2021, 266 mechanically ventilated adults with COVID-19 were enrolled across 5 UK hospital intensive care units (ICUs).
Mechanisms of Acute Right Ventricular Injury in Cardiothoracic Surgical and Critical Care Settings: Part 2.
J Cardiothorac Vasc Anesth
November 2023
Article Synopsis
- The right ventricle (RV) plays a crucial role in critical illness, but its functions and pathologies are less understood compared to the left ventricle, leading to a greater need for study.
- With the rise of point-of-care echocardiography in critical care, there's a growing ability to detect and monitor RV issues in patients earlier than before.
- The article discusses different states of RV injury, highlighting a lack of a universal definition and emphasizing the importance of understanding RV-pulmonary circulation dynamics to improve diagnosis and treatment.
Background: Research from sub-Saharan Africa that contributes to our understanding of the 2022 mpox (formerly known as monkeypox) global outbreak is insufficient. Here, we describe the clinical presentation and predictors of severe disease among patients with mpox diagnosed between Feb 1, 2022, and Jan 30, 2023 in Nigeria.
Methods: We did a cohort study among laboratory-confirmed and probable mpox cases seen in 22 mpox-treatment centres and outpatient clinics across Nigeria.
Background: Bleeding and thrombosis are major complications of veno-venous (VV) extracorporeal membrane oxygenation (ECMO).
Objectives: To assess thrombosis, major bleeding (MB), and 180-day survival in patients supported by VV-ECMO between the first (March 1 to May 31, 2020) and second (June 1, 2020, to June 30, 2021) waves of the COVID-19 pandemic.
Methods: An observational study of 309 consecutive patients (aged ≥18years) with severe COVID-19 supported by VV-ECMO was performed in 4 nationally commissioned ECMO centers in the United Kingdom.
Background: Cardiogenic shock (CGS) occurs in 10% of patients presenting with acute myocardial infarction (MI), with in-hospital mortality rates of 40-50% despite revascularisation.
Aims: The EURO SHOCK trial aimed to determine if early use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) could improve outcomes in patients with persistent CGS following primary percutaneous coronary intervention (PPCI).
Methods: This multicentre, pan-European trial randomised patients with persistent CGS 30 minutes after PPCI of the culprit lesion to receive either VA-ECMO or continue with standard therapy.
Right ventricular injury (RVI) in the context of acute respiratory distress syndrome (ARDS) is well recognized as an important determinant risk factor of mortality. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is part of the algorithm for the management of patients with severe ARDS and severely impaired gas exchange. Although VV-ECMO may theoretically protect the RV it is uncertain to what degree RVI persists despite VV-ECMO support, and whether it continues to influence mortality after ECMO initiation.
View Article and Find Full Text PDFObjectives: Nigeria reported an upsurge in cholera cases in October 2020, which then transitioned into a large, disseminated epidemic for most of 2021. This study aimed to describe the epidemiology, diagnostic performance of rapid diagnostic test (RDT) kits and the factors associated with mortality during the epidemic.
Design: A retrospective analysis of national surveillance data.
Thrombosis and coagulopathy in COVID-19 patients rceiving ECMO: A narrative review of current literature.
J Cardiothorac Vasc Anesth
August 2022
Extracorporeal membrane oxygenation (ECMO) is an established part of the treatment algorithm for coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. An intense inflammatory response may cause an imbalance in the coagulation cascade making both thrombosis and bleeding common and notable features of the clinical management of these patients. Large observational and retrospective studies provide a better understanding of the pathophysiology and management of bleeding and thrombosis in COVID-19 patients requiring ECMO.
View Article and Find Full Text PDFBleeding and thrombosis are major complications in patients supported with extracorporeal membrane oxygenation (ECMO). In this multicentre observational study of 152 consecutive patients (≥18 years) with severe COVID-19 supported by veno-venous (VV) ECMO in four UK commissioned centres during the first wave of the COVID-19 pandemic (1 March to 31 May 2020), we assessed the incidence of major bleeding and thrombosis and their association with 180-day mortality. Median age (range) was 47 years (23-65) and 75% were male.
View Article and Find Full Text PDFObjective: There is a paucity of sex-specific data on patients' postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO). The present study sought to assess this issue in a multicenter study.
Design: Retrospective, propensity score-matched analysis of an international registry.