Publications by authors named "Yusuf T Abaci"
Article Synopsis
- The assembly of the mammalian brain involves coordinated gene expression and is significantly influenced by microRNAs (miRNAs), particularly miR-218.
- Deleting neuron-specific miRNAs leads to major developmental issues, and changes in miRNA levels are seen in neurodevelopmental disorders, indicating their importance in brain development.
- miR-218 plays a crucial role in organizing the hippocampus and maintaining stable neural networks by regulating excitatory and inhibitory neuron functions, with its inhibition causing structural and functional impairments that predispose the brain to seizures.
CRISPR/Cas9 is a popular genome editing technology. Although widely used, little is known about how this prokaryotic system behaves in humans. An unwanted consequence of eukaryotic Cas9 expression is off-target DNA binding leading to mutagenesis.
View Article and Find Full Text PDFAberrant androgen signaling drives prostate cancer and is targeted by drugs that diminish androgen production or impede androgen-androgen receptor (AR) interaction. Clinical resistance arises from AR overexpression or ligand-independent constitutive activation, suggesting that complete AR elimination could be a novel therapeutic strategy in prostate cancers. IRC117539 is a new molecule that targets AR for proteasomal degradation.
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