Correlation of hyperglycemia and balthazar classification in patients with acute pancreatitis.

Objective: High levels of glucose during acute pancreatitis (AP) progression influence disease progression by promoting the release of inflammatory cytokines. The aim of this study was to evaluate the effects of both the blood glucose level in patients without diabetes mellitus (DM) and the presence of DM on the severity and course of AP in patients presenting with clinical AP.

Methods: The study included 343 patients who were hospitalized at Van Training and Research Hospital, Turkey and followed up with the diagnosis of AP between 2014 and 2018.

Amoxicillin, gemifloxacin and rabeprazole, as first-line Helicobacter pylori therapy in clinical practice: A pilot study.

Success in eradication of H. pylori is decreasing due to increasing resistant strains. In particular, side-effects due to 4-agent treatment multiple drug use are observed and treatment compliance decreases.

Electrogastrography in patients with gastric motility disorders.

Electrogastrography (EGG) is a novel diagnostic modality for assessing the gastrointestinal tract (GI) that generates spontaneous electrical activity and monitors gastric motility. The aim of this study was to compare patients with functional dyspepsia (FD) and diabetic gastroparesis (D-GP) with healthy controls (CT) to use established findings on abnormalities of gastric motility based on EGG characteristics. In this study, 50 patients with FD, 50 D-GP patients, and 50 CT subjects were studied to compare EGG with discrete wavelet transform models (DWT) to extract signal characteristics using a variety of different qualitative and quantitative metrics from pre-prandial and postprandial states.

Mucocutaneous Manifestations and Associated Factors in Patients with Crohn's Disease.

Background: One-third of all extraintestinal manifestations are mucocutaneous findings in patients with Crohn's disease and there is a relationship between some risk factors. Our aim is to evaluate factors associated with mucocutaneous manifestations in our cohort of patients with Crohn's disease with a follow-up duration of up to 25 years.

Methods: In the study, 336 patients with Crohn's disease who were followed up between March 1986 and October 2011 were included.

Is there a correlation between the initial calcium level and Balthazar classification in patients with acute pancreatitis?

Background: While a life-threatening course is observed in 2-3% of patients with acute pancreatitis (AP), mortality can be up to 50% in severe AP. In our study, we research relationship between calcium level and Modified Balthazar (MB) score.

Methods: 354 patients who were followed up with a diagnosis of AP between 2013 and 2019 were included in our study.

Can neutrophil-lymphocyte ratio predict mortality in acute non-variceal upper gastrointestinal bleeding?

Background: Acute non-variceal upper gastrointestinal bleeding (NVUGIB) is one of the common gastrointestinal problems and has a high mortality, especially in patients with poor hemodynamics. Therefore, treatment and follow-up should be managed dy-namically. Neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are fast workable, cheap, and easy to calculate he-matological parameters.

Electrogastrography in Patients with Functional Dyspepsia, Joint Hypermobility, and Diabetic Gastroparesis.

Background: Transcutaneous electrogastrography is a novel modality to assess the human stomach's gastric myoelectrical activity. The purpose of this study was to compare functional dyspepsia, joint hypermobility, and diabetic gastroparesis patients with healthy control subjects in terms of gastric motility abnormalities through electrogastrography evaluations, and to then evaluate the correlation among variations in their blood parameters.

Methods: This study analyzed 120 subjects with functional dyspepsia (n = 30), joint hypermobility (n = 30), diabetic gastroparesis (n = 30), and control subjects (n = 30).

Hepatitis B Reactivation in Patients Treated with Direct-Acting Antivirals for Hepatitis C.

Introduction: There is limited research about HBV reactivation (HBVr) due to direct-acting antivirals (DAA) for HCV and most are limited by short duration of follow-up, small sample size, and absence of baseline HBV DNA. We aimed to determine the incidence and clinical course of HBVr in HBsAg and/or anti-HBcIgG positive patients treated with DAA for HCV.

Methods: Seven centers retrospectively analyzed their database on HCV patients treated with DAA between 2015 and 2019.

Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?

Background: Hepatocellular carcinoma (HCC) is one of the important causes of mortality due to malignancy. Toll-like receptors (TLRs) are very important in liver pathophysiology in terms of their roles in the innate immune system, such as the regulation of inflammation, wound healing, stimulation of adaptive immune responses, promotion of epithelial regeneration, and carcinogenesis. In this study, we planned to examine the role of TLR1 (rs4833095, rs5743551) and nucleotide-binding oligomerization domain (NOD2) (rs2066844, rs2066845, rs2066847) polymorphisms in the development of HCC and their effects on the clinical presentation of HCC patients.

Gallstone Frequency in Children With Celiac Disease.

Introduction Celiac disease (CD) is a chronic autoimmune systemic disease caused by the T cell-driven immune mechanism, which is triggered by gluten in cereals such as wheat, barley, and rye in individuals who have a genetic predisposition. The purpose of the present study was to investigate the frequency of gallstones in children with CD. Methods A total of 120 patients who were diagnosed with CD and who were followed-up by the pediatric gastroenterology clinic of the hospital and 100 healthy children were included in the study.

Demographic, Laboratory, and Clinical Comparison of Pediatric Brucella Cases With and Without Liver Involvement.

Introduction In this study, the purpose was to compare the demographic, clinical, and laboratory results of pediatric cases with and without liver involvement. Methods The data of 248 patients between 2 and 18 years of age at diagnosis with Brucellosis between July 2017 and August 2018 were analyzed retrospectively. Liver involvement was defined as elevated transaminase enzymes when compared to levels of the control group.

Diagnosis and Treatment of Fasciola Hepatica With Endoscopic Retrograde Cholangiopancreatography in a Child Patient: Case Report.

(FH) is a parasite that causes fever, hepatomegaly, abdominal pain, weight loss, anemia, and eosinophilia in the acute period, and jaundice, pancreatitis, and cholangitis in the chronic period by settling in the bile ducts. A 13-year-old girl admitted with abdominal pain, nausea, and jaundice. In her hemogram, the patient had leukocytosis and eosinophilia.

Clinical outcomes of acute pancreatitis in elderly patients: An experience of single tertiary center.

Background: Although well understanding the course of diseases in geriatric population is of paramount importance in order to provide the optimal treatment, there is only a few studies with controversial results that have been conducted about the course and outcomes of acute pancreatitis (AP) in elderly. We aimed to compare clinical outcomes of AP disease in geriatric age group and to evaluate the risk factors affecting outcomes.

Methods: A total of 336 patients diagnosed with AP, hospitalized and followed-up in our hospital between July/2013-February/2019 were included in this study.

The Severity of Acute Pancreatitis According to Modified Balthazar Classification in Patients With Pancreatic Cancer.

Objective: Although acute pancreatitis (AP) is a self-limited disease under supportive and medical treatment, it can have life-threatening potential in some patients. Results of studies reporting outcomes of AP-associated pancreatic malignancy are controversial. The aim of this study was to evaluate the severity and prognosis of pancreatic cancer (PC)-related AP by modified Balthazar score.

The development of extraintestinal manifestation and related risk factors in Crohn's patients.

Background: Crohn's disease (CD) primarily involves gastrointestinal tract; however, it can present with extraintestinal manifestations (EIMs), which leads to significant morbidity. Frequency of EIMs and associated risk factors vary due to genetic and environmental differences in studies.

Aim: To examine the frequency and risk factors associated with EIMs in CD.

Eating disorders in patients with irritable bowel syndrome.

Introduction: Eating disorders (ED) constitute an important group of conditions that commonly occur in adolescents. Gastrointestinal complaints are frequently reported in ED patients. Few studies assessed the association of irritable bowel syndrome (IBS) with ED.

Can Hematological Inflammatory Parameters Predict Mortality in Hepatocellular Carcinoma?

Purpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Inflammatory and hematological parameters such as neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) provided useful information especially in the diagnosis, treatment, and follow-up of malignancies. In this study, we planned to demonstrate the efficacy of NLR and PLR levels in the evaluation of the prognosis of patients with HCC in our clinic.

The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of and on Gastritis in Childhood.

Although there are many studies that investigate the relationship between duodenogastric reflux (DGR) and in adult patients, the reported data are contradictory. In addition, there are very few studies in the literature investigating the relationship between DGR and in the pediatric age group. In the present study, we investigated the effect of primary DGR on and gastritis.

Association of autoimmune diseases with celiac disease and its risk factors.

Objectives: Autoimmune Diseases (AIDs) are detected in celiac patients. Our purpose was to determine the AIDs that are associated with celiac disease and related risk factors in the Turkish population.

Methods: The study included 230 celiac patients who were diagnosed and followed-up in our clinics between 2015-2019.

May Neutrophil Gelatinase-Associated Lipocalin (NGAL) Level Predict Mortality in Patients with Hepatocellular Carcinoma (HCC)?

Purpose: Hepatocellular carcinoma (HCC) ranks fifth among the common cancers worldwide. Hepatocarcinogenesis is a multiple-phases process, which involves changes in cellular genomes including high cell proliferation.In this study, we aimed to evaluate the relationship of NGAL level at the time of diagnosis with mortality in patients diagnosed with HCC.

Risk factors associated with progression to intestinal complications of Crohn disease.

Background: Crohn disease is a chronic bowel disease that causes serious complications. Prevalence of Crohn disease is increasing. Studies have shown that the behavior of the disease is not stable and severe complications secondary to behavior change over time have been shown.

Chronic hepatitis C infection: how much are physicians aware of?

Aim: The purpose of our study is to measure the awareness of hepatitis C among physicians employed in Istanbul, and investigate the relationship between awareness and the specialization field, age and presence of chronic hepatitis/positive family history.

Material And Methods: Level of awareness of 125 family physicians and 76 internal medicine physicians, employed within Istanbul Province, on hepatitis C infection were evaluated using standard questionnaire. Relationship between their awareness and age, specialization, presence of any chronic hepatitis and chronic hepatitis C in any relatives were investigated.

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit.

Background: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings.