Effect of adropin on seizure activity in rats with penicillin-induced epilepsy.

Background: Epilepsy is a nervous system disease that affects millions of individuals worldwide, and up to 25% of patients have seizures that are resistant to antiepileptic drugs. Therefore, there is a need for the discovery of tolerable, effective antiepileptic agents. This study was aimed to electrophysiologically investigate the effects of the peptide hormone adropin, which was discovered in recent years and whose expression was determined in many organs, on penicillin-induced epileptiform activity in rats.

Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease.

Background: Celiac disease (CD) is an autoimmune disorder triggered by gluten consumption. Almost all CD patients possess human leukocyte antigen (HLA) DQ2/DQ8 haplotypes; however, only a small subset of individuals carrying these alleles develop CD, indicating the role of environmental factors in CD pathogenesis. The main objective of this study was to determine the contributory role of gut microbiota and microbial metabolites in CD onset.

Effects of zinc treatment in patients with recurrent aphthous stomatitis.

The purpose of this study was to assess the effects of systemic zinc sulfate in the treatment of recurrent aphthous stomatitis (RAS) by atomic absorption spectrophotometry. The study was carried out on 40 patients with RAS. The first group consisted of 20 subjects with RAS who were administered zinc sulfate (220 mg) once per day for one month.

Trace elements and some extracellular antioxidant protein levels in serum of patients with laryngeal cancer.

In this study, we investigated the levels of serum Zn, Cu, Mg, Mn, Fe, ceruloplasmin (Cp), transferrin (Trf), and albumin in laryngeal carcinoma and correlated their levels with the cancer stage. The sera from 35 patients with laryngeal cancer (10 at stage II, 12 at stage III, and 13 at stage IV) were extracted before treatment and compared with those from the healthy control group (n=15). Although serum Fe and Mn concentrations were lower in the laryngeal cancer groups (for all stages) than in the control group, the difference was not statistically significant (p>0.