Publications by authors named "Yusuf A Jega"
The inhibitory potential of , a well-known antimalarial herb, against several viruses, including the coronavirus, is increasingly gaining recognition. The plant extract has shown significant activity against both the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the novel SARS-CoV-2 that is currently ravaging the world. It is therefore necessary to evaluate individual chemicals of the plant for inhibitory potential against SARS-CoV-2 for the purpose of designing drugs for the treatment of COVID-19.
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- The study investigates compounds from a plant source (Prance ex F. White) for their potential to inhibit the SARS-CoV-2 virus causing COVID-19, which currently lacks approved treatments or vaccines.
- Molecular docking simulations and ADMET analysis were conducted on compounds such as catechin and quercetin to assess their ability to bind to key proteins of the virus and predict their pharmacokinetic properties.
- Results indicate these compounds could effectively bind to SARS-CoV-2 proteins and show promising pharmacokinetic profiles, suggesting they may serve as potential therapeutic agents against COVID-19 in future research.
Anti-proliferative activity of the ethyl acetate fractions of Ochna schweinfurthiana F. Hoffm. and Ochna kibbiensis Hutch.
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