Para-Bombay blood group: Report of a rare blood group.

Para-Bombay blood group is a rare blood group typically characterized by the absence of H antigens on red blood cell and the presence of ABH substances on secretion. It can be easily missed and often mistaken as blood group O without extended testing. Detection is important as it significantly affect transfusion management.

In-depth analysis of lupeol: delving into the diverse pharmacological profile.

Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in various edible vegetables, fruits, and medicinal plants. Notably, it is found in high concentrations in plants like , , and , among others. Quantitative studies have highlighted its presence in Elm bark, Olive fruit, Aloe leaf, Ginseng oil, Mango pulp, and Japanese Pear bark.

Multimorbidity is associated with myocardial DNA damage, nucleolar stress, dysregulated energy metabolism, and senescence in cardiovascular disease.

This study investigates why individuals with multimorbidity-two or more chronic conditions-are more prone to adverse outcomes after surgery. In our cohort, ninety-eight of 144 participants had multimorbidity. The myocardial transcriptome and metabolites involved in energy production were measured in 53 and 57 sequential participants, respectively.

Abundance of microplastics and its ecological risk assessment in coral reef regions of Peninsular Malaysia.

Microplastic contamination is an emerging concern in marine ecosystems, with limited knowledge on its impact on coral reefs, particularly in Malaysia. Surface waters were collected from several coral reef regions in Peninsular Malaysia by towing a plankton net behind the boat. Microplastics were detected at all sites, with a mean abundance of 0.

Eco-friendly natural rubber-based hydrogel loaded with nano-fertilizer as soil conditioner and improved plant growth.

This study addresses the dual challenge of agricultural cost and waste management by harnessing agrarian waste to produce nano-fertilizers (NF) to enhance crop yield while mitigating environmental impacts. Recognizing the limitations of traditional hydrogels' non-biodegradability and their inability to sustain root zone moisture and nutrient levels, we developed an LNR/AAc/pectin hydrogel. This innovative hydrogel offers a viable solution that provides a consistent NF supply and improves water retention efficiently.

Integration of IoT in Small-Scale Aquaponics to Enhance Efficiency and Profitability: A Systematic Review.

Aquaponics combines aquaculture and hydroponics to offer a sustainable approach to agriculture, addressing food security issues with minimal environmental harm. However, small-scale practitioners face challenges due to a lack of professional knowledge in water chemistry and system maintenance. Economic hurdles, such as operational costs and energy-intensive components, hinder the viability of small-scale aquaponics.

The Importance of Molecular Biological Analysis for the Laboratory Diagnostic of Homozygous Haemoglobin Malay.

Haemoglobin (Hb) Malay is variant haemoglobin with a β thalassemia phenotype. The prevalence of Hb Malay in the Malaysian population was 5.5%.

Suprasellar pilocytic astrocytoma with leptomeningeal dissemination.

Unlabelled: Leptomeningeal dissemination is a rare manifestation of pilocytic astrocytoma. It may occur with higher-grade tumours like medulloblastoma, ependymoma and high-grade glioma, but is extremely rare with low-grade glioma. There has been a growing number of reported cases documenting leptomeningeal dissemination of pilocytic astrocytoma in the medical literature.

Development and Validation of a Low-Cost Drilling Model.

Simulation models enable learners to have repeated practise at their own time, to master the psycho-motor and sensory acuity aspects of surgery and build their confidence in the procedure. The study aims to develop and evaluate the feasibility of a low-cost drilling model to train surgeons in the drilling task. The model targets three aspects of drilling - (1) Reduce plunge depth, (2) Ability to differentiate between bone and medullary canal and (3) Increase accuracy drilling in various angles.

Effect of indomethacin on embryo implantation and histomorphology of uterus, ovary, kidney, and liver of rats.

Background: This study aimed to determine the effects of Indomethacin (IMC) treatment on embryo implantation and histomorphology of uterus, ovary, and other vital organs and its effective dosage in establishing embryo implantation dysfunction model in Sprague-Dawley (SD) rats.

Materials And Methods: The experiments were performed on 24 (6 × 4 groups) adult female SD rats aged 12 weeks old. G1 was the control group and received a normal diet with normal saline.

Novices can assess microsurgery performance, and this is enhanced using the Manual Suture Parameters for Training and Assessment (M-SParTA) scoring system.

This study explores how novices could effectively evaluate the quality of microsurgical suturing. That would be enhanced with using a novel Manual Suture Parameters for Training and Assessment (M-SParTA), which supported novices with guidance on the objective parameters, in order to increased the accuracy of scoring ability. We also propose the following initial framework to train novices in microsuturing using a standardised task: 1) Exposure; 2) Assessment; 3) Hands-on and self-assessment.

Performance Comparison Between Conventional Fluorescent Spot Test and Quantitative Assay in Detecting G6PD Deficiency in Neonates.

Objectives: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy worldwide. The fluorescent spot test (FST) is the conventional method for screening neonates for G6PD. However, it has limitations and quantitative assays such as the CareStart Biosensor 1 are being increasingly recommended.

Characteristics of ABO Antibodies in Group O Malaysian Blood Donors.

Background: Haemolytic transfusion reactions (HTRs) due to anti-A and anti-B antibodies in Group O blood products are rare but potentially fatal. This study aimed to identify the prevalence of high ABO antibody titre and the immunoglobulin (Ig) classes (IgM only or with IgG) and the prevalence of haemolysin antibodies in Group O blood donors.

Methods: Plasma from Group O blood donors was tested by using antibody titration at room temperature.

The Validity and Reliability of Malay Version Child Exposure to Domestic Violence Scale.

Background: Domestic violence has a significant impact on growing children. However, existing evidence is limited and often under reported. Consequently, the Child Exposure to Domestic Violence (CEDV) scale has been developed for global use.

Psychometric properties of the Malay version of the difficulties in Emotion Regulation Scale-18 in Malaysian adolescents.

Objective: The Difficulties in Emotion Regulation Scale-18 (DERS-18) is an instrument used to measure deficits in emotion regulation. However, the instrument has not been adapted to Malaysians and has never been validated in the Malay language. This study aimed to examine the psychometric properties of the Malay version of DERS-18.

Significance of Zone 2 Peak on Capillary Electrophoresis in the Detection of Hemoglobin Constant Spring.

Objectives: Hemoglobin constant spring (Hb CS) is a point mutational defect associated with α thalassemia. The aims of this study were to compare the hematological profiles between different Hb CS genotypes and to estimate the range for Zone 2 peak using capillary electrophoresis (CE) with different Hb CS genotypes.

Methods: For this cross-sectional study, patient blood samples that showed a positive peak in zone 2 of CE were selected.

Immune-mediated necrotizing myopathy (NAM) related to SARS-Cov-2 infection: a case report.

Background: There is a growing body of evidence that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or COVID-19 infection is associated with the development of autoimmune diseases. A recent systematic review reported that the new-onset autoimmune disorders during or after COVID-19 infection included inflammatory myopathies such as immune-mediated necrotizing myopathies.

Case Presentation: We described a 60-year-old man diagnosed with COVID-19 infection and later presented with a two-week history of myalgia, progressive limb weakness, and dysphagia.

Tai Chi Exercise for Mental and Physical Well-Being in Patients with Depressive Symptoms: A Systematic Review and Meta-Analysis.

Tai Chi is a mindfulness-body practice that has physiological and psychosocial benefits and can be integrated into the prevention and rehabilitation of various medical conditions; however, the effectiveness of Tai Chi in the treatment of depression remains unclear. This review aimed to determine the effects of Tai Chi exercise on mental and physical well-being in patients with depressive symptoms. We searched databases for English language publications that appeared during January 2000-2022.

Chicken Feet: A Model for Practising Locoregional Flaps of the Hand.

The aim of this study was to determine the feasibility of the chicken foot model for surgical trainees interested in practising the designing, harvesting and inset of locoregional flaps of the hand. A descriptive study was performed to demonstrate the technical aspects of harvesting four locoregional flaps in a chicken foot model: fingertip volar V-Y advancement flap, four-flap and five-flap Z-plasty, cross-finger flap and first dorsal metacarpal artery (FDMA) flap. The study was performed in a surgical training laboratory on non-live chicken feet.

Pharmacological activities and mechanisms of action of hypophyllanthin: A review.

Hypophyllanthin is a major lignan present in various species and has been used as one of the bioactive chemical markers for quality control purposes as it contributes to their diverse pharmacological activities. The objective of this study is to compile up-to-date data on the pharmacological actions and mechanisms of hypophyllanthin. This review also includes the extracts of species whose pharmacological actions have been partially attributed to hypophyllanthin.

A case of naturally occurring anti-Di antibody in a young man.

The Diego (Di) blood group system comprises 22 antigens located on the band 3 protein, most of which are low-prevalence antigens. The majority of antibodies to Diego system antigens were of clinically insignificant; however anti-Dia, -Dib, -Wra, -ELO and-DISK may cause hemolytic disease of the fetus and newborn (HDFN) and transfusion reaction. We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury.

Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization.

Vascular amyloidosis, caused when peptide monomers aggregate into insoluble amyloid, is a prevalent age-associated pathology. Aortic medial amyloid (AMA) is the most common human amyloid and is composed of medin, a 50-amino acid peptide. Emerging evidence has implicated extracellular vesicles (EVs) as mediators of pathological amyloid accumulation in the extracellular matrix (ECM).