Publications by authors named "Yusi Zhang"

Background: Aerobic exercise training can promote the recovery of learning and memory ability in Alzheimer's disease (AD), but the specific mechanism is still unclear. Previous studies have suggested that aquaporin-4 (AQP4)-mediated glymphatic system is an important way to clear β-amyloid (Aβ) in the brain, which is closely related to learning and memory impairment in AD. However, it remains unclear whether AQP4 regulates glymphatic clearance of Aβ which contributes to the beneficial effects of aerobic exercise in AD patients.

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  • Lumbar disc herniation (LDH) is a prevalent source of lower back pain and sciatica, with posterior lumbar interbody fusion (PLIF) being a standard treatment method, prompting a study on predicting blood transfusion needs during surgery.
  • This study involved 6,241 patients across 22 medical centers in China and utilized various machine learning techniques to create an optimal predictive model for intraoperative blood transfusion using robust evaluation methods.
  • The best-performing model, a simulated annealing support vector machine recursive + stacking model, achieved an area under the curve of 0.884, leading to the creation of a publicly accessible web calculator to aid clinicians in decision-making and improve patient management.
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The Qa-1 in mice is homologous to human leukocyte antigen E(HLA-E), and both of them belong to the non-classical major histocompatibility complex I b(MHC-I b) molecules. Qa-1 is capable of presenting self or exogenous antigen peptides to interact with two distinct receptors, namely T cell receptor (TCR) and natural killer cell group 2 member A (or C) (NKG2A/C), thus playing an important role in immune response and regulation. Qa-1-restricted regulatory CD8 T cell (CD8 Treg) is one of the most studied CD8 Treg subgroups, which can maintain immune homeostasis and autoimmune tolerance by exerting immunosuppressive effects.

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  • The study aimed to analyze the characteristics of normal human peripheral blood neutrophils, focusing on their surface markers and functional properties.
  • Neutrophils were categorized into three subsets based on CD16 expression levels, with findings indicating that CD16+ neutrophils were the most abundant and showed the highest phagocytic activity.
  • The research also highlighted differences in the expression of inhibitory molecules (like PD-L1 and CD300LD) across neutrophil subsets and examined their morphology during extracellular trap formation.
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  • - The research focuses on developing a clinical model to predict which patients undergoing posterior lumbar interbody fusion (PLIF) for lumbar spinal stenosis are likely to experience prolonged surgical times, which can lead to complications and affect recovery.
  • - A total of 3,233 patients from 22 hospitals in China from 2015 to 2022 were included in the study, and their data was analyzed using machine-learning techniques to identify key factors associated with longer surgery durations.
  • - The study utilized a training cohort and four test groups, applying various algorithms and performance evaluations to create a predictive model, ultimately aiming to enhance patient safety and surgical outcomes.
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Background: Different hormone receptor (HR) expression patterns have significant biological and therapeutic implications in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, the distinction between HR-positive /HER2-positive (HR+/HER2+) and HR-negative/HER2-positive (HR-/HER2+) subtypes remains unclear.

Methods: This retrospective study analyzed 828 patients with HER2-positive breast cancer at the First Affiliated Hospital of Xi'an Jiaotong University from 2012 to 2022.

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CX3CL1, also named fractalkine or neurotactin, is the only known member of the CX3C chemokine family that can chemoattract several immune cells. CX3CL1 exists in both membrane-anchored and soluble forms, with each mediating distinct biological activities. CX3CL1 signals are transmitted through its unique receptor, CX3CR1, primarily expressed in the microglia of the central nervous system (CNS).

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Natural killer (NK) cells directly lysis the virus-infected cells through rapidly releasing cytotoxic mediators and cytokines. The balance between inhibitory and activated receptors on the surface of NK cells, as well as the corresponding ligands expressed on target cells are involved in the regulation of the cytotoxic function of NK cells. NKG2A is one of the highly anticipated inhibitory receptors expressed on NK cells, which can inhibit the cytotoxicity of NK cells to autologous normal tissue cells through interacting with the ligand HLA-E.

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  • The research focused on creating a machine learning model to predict the risk of extended hospital stays before surgery, aiming to enhance patient management.
  • Patients who had posterior spinal deformity surgery in China between 2015 and 2022 were included, and their preoperative data was analyzed using various machine learning techniques to identify risk factors.
  • The K Nearest Neighbors algorithm was the most effective in predicting prolonged hospitalization, with key factors including preoperative hemoglobin, height, BMI, age, and white blood cells, leading to the development of a web-based calculator for practical use.
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We evaluated cellular immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in an immunized population based on HLA-E-restricted CD8 T cell epitope identification. HLA-E-restricted SARS-CoV-2 CD8 T cell nonamer peptides were predicted with software. An HLA-E-transfected K562 cell binding assay was used to screen for high-affinity peptides.

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  • This study focused on understanding brain changes that occur before individuals develop mild cognitive impairment (MCI), a key warning sign of dementia.
  • Researchers compared two groups of older adults: those with progressive normal cognition (pNC) at risk for MCI and those with stable normal cognition (sNC), examining their brain structure and function through MRI.
  • Findings revealed that the pNC group had reduced gray matter in specific brain areas and increased functional connectivity related to dopamine and noradrenaline, suggesting measurable brain changes could help identify those at risk for MCI.
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Background: Developmental dyslexia (DD) is a neurodevelopmental disorder that is characterized by difficulties with all aspects of information acquisition in the written word, including slow and inaccurate word recognition. The neural basis behind DD has not been fully elucidated.

Method: The study included 22 typically developing (TD) children, 16 children with isolated spelling disorder (SpD), and 20 children with DD.

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Objectives: Deficits in verbal working memory (VWM) observed in attention deficit hyperactivity disorder (ADHD) children can persist into adulthood. Although previous studies have identified brain regions that are activated during VWM tasks, the neural mechanisms underlying the relationship between VWM deficits remain unclear. The objective of this study was to investigate the structural covariance network connectivity and brain morphology changes that are associated with VWM performance in ADHD children.

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CD226 is an activated receptor on the surface of natural killer (NK) cells. It competes with TIGIT and CD96 to bind to ligands such as CD155 on the surface of tumor cells and mediates the killing function of NK cells. Although TIGIT and CD96 have other binding ligands in the tumor microenvironment, they compete to bind CD115 ligands with higher affinity and inhibit the activity of NK cells, which allows tumor cells to evade killing.

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Skull stripping is a key step in the pre-processing of rodent brain magnetic resonance images (MRI). This study aimed to develop a new skull stripping method via U-Net, a neural network model based on deep learning method, for rat brain MRI.In this study, 599 rats were enrolled and U-Net was applied to segment MRI images of rat brain.

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Although aging and apolipoprotein E (APOE) ε4 allele have been documented as two major risk factors for late-onset Alzheimer's disease (LOAD), their interaction and potential underlying mechanisms remain unelucidated. Using humanized ApoE4- and ApoE3- target replacement mice, we found the accumulation of senescent neurons and the activation of mTOR and endosome-lysosome-autophagy (ELA) system in the hippocampus of aged ApoE4 mice. Further analyses revealed that ApoE4 aggravated the profile change of hippocampal transcription and metabolism in an age-dependent manner, accompanying with an disruption of metabolism, which is presented with the downregulating activity of citrate synthase, the level of ATP and, most importantly, the level of acetyl coenzyme A (Ac-CoA); GTA supplement, an Ac-CoA substrate, reversed the senescent characteristics, decreased the activation of mTOR and ELA system, and enhanced the synaptic structure and increasing level of pre-/post-synaptic plasticity-related protein, leading to cognitive improvement in aged ApoE4 mice.

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Background: Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS). Inflammatory monocytes (iMOs) are involved in early antiviral responses. Previous studies have found that blood iMOs numbers increase in the acute phase of HFRS.

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The cell wall of Auricularia auricula fruit bodies is extremely tough, making it difficult to dissolve the melanin using the traditional preparation method. To investigate the efficient preparation of melanin and its resistance to oxidative stress, this paper first used ultrasound-assisted alkaline cellulase to optimize the optimal wall-breaking parameters through a Box-Behnken design based on a single-factor experiment. After optimization, the yield of melanin from A.

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With the improvement of diagnostic techniques, numerous uncommon metastases derived from breast cancer were reported. However, very few studies explored the clinical characteristics and prognostic patterns of these patients. A total of 82 cases of uncommon metastatic breast cancer (MBC) registered at our hospital from January 1, 2010, to July 1, 2022, were selected for this retrospective study.

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The concept of "ntigen"is a relative one. The narrow concept of it condenses the process of activation of adaptive immune response and re-recognition of the same antigen, revealing the protective mechanism of vaccines with great significance for research and development of vaccines. However, the narrow concept involves adaptive immune system members: B cells, T cells and their effector products, which is difficult for beginners to understand the inherent meaning.

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Infection with the Hantaan virus (HTNV) may result in severe hemorrhagic fever with renal syndrome (HFRS). The functions of HLA-E-restricted CD8 T lymphocytes in virus control and vaccine development have recently received increased attention. The purpose of this research is to discover HLA-E-restricted CD8 T cell epitopes on HTNV as well as the features of these epitope-specific CD8 T cells in HFRS patients.

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Objective To investigate the relationship between disease courses and severity and monocyte subsets distribution and surface CD31 intensity in patients of hemorrhagic fever with renal syndrome (HFRS). Methods Peripheral blood samples from 29 HFRS patients and 13 normal controls were collected. The dynamic changes of classical monocyte subsets (CD14CD16), intermediated monocyte subsets (CD14CD16) and non-classical monocyte subsets (CD14CD16) and the mean fluorescent intensity (MFI) of CD31 on monocyte subsets were detected by multiple-immunofluorescent staining and flow cytometry.

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China is one of the main epidemic areas for hemorrhagic fever with renal syndrome (HFRS). Currently, there is no human antibody specific to Hantaan virus (HTNV) for the emergency prevention and treatment of HFRS. To prepare human antibodies with neutralizing activity, we established an anti-HTNV phage antibody library using phage display technology by transforming peripheral blood mononuclear cells (PBMCs) of patients with HFRS into B lymphoblastoid cell lines (BLCLs) and extracting cDNA from BLCLs that secreted neutralizing antibodies.

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A. Baumannii is an opportunistic nosocomial pathogen which has severe antibiotic resistance. However, the epidemiology is less clearly understood in Jilin province and China.

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