Characterization of CRISPR-Cas systems in Leptospira reveals potential application of CRISPR in genotyping of Leptospira interrogans.

Leptospirosis is a zoonotic disease caused by pathogenic Leptospira. However, understanding of the pathogenic mechanism of Leptospira is still elusive due to the limited number of genetic tools available for this microorganism. Currently, the reason for the genetic inaccessibility of Leptospira is still unknown.

Identification and Characterization of c-di-GMP Metabolic Enzymes of and c-di-GMP Fluctuations After Thermal Shift and Infection.

Leptospirosis is a widespread zoonotic disease caused by pathogenic species. The most common species, , can transfer from contaminated soil or water to the human body. It is able to survive these changing environments through sensing and responding to the changes of environmental cues.