Publications by authors named "Yushuang Tan"
Cancer Commun (Lond)
December 2024
Article Synopsis
- Immunotherapy for nasopharyngeal carcinoma (NPC) is effective but has low response rates; the role of PD-L1 on small extracellular vesicles (sEVs) in tumor immunosuppression is a key focus of research.
- The study investigates how the Epstein-Barr virus protein LMP1 influences tumor immunity in NPC by analyzing T cell presence and sEV characteristics in both human tissues and mouse models.
- Results show that high LMP1 levels limit CD8 T cell infiltration and promote PD-L1 secretion through interactions with ALIX, suggesting a potential pathway for therapeutic intervention to enhance immune responses in NPC.
