Publications by authors named "Yushu Zou"
Optimising vaccine immunogenicity in ageing populations: key strategies.
Lancet Infect Dis
January 2025
Article Synopsis
- Vaccination is really good at stopping infectious diseases, but older people (65 and up) often don't respond well to vaccines, making them less protected.
- The Review explains why older people's immune systems are weaker, mentioning things like aging, changes in genes, and gut health.
- It also talks about new ideas and strategies that could help make vaccines work better for older folks in the future.
Article Synopsis
- Ferroptosis is linked to the loss of dopaminergic neurons in Parkinson's disease (PD), with Hspb1 levels being elevated in patients' brains, but its exact role is not fully understood.
- Researchers used dopaminergic neurons from human iPSCs and a compound called Coniferaldehyde (CFA) to study how Hspb1 and Nrf2 interact and their impact on neuroprotection in PD.
- The study found that Nrf2 can activate Hspb1, crucial for the protective effect of CFA; however, excessive Hspb1 ultimately leads to neuronal death and inflammation, revealing a complex role in PD that needs further exploration for potential therapies.
Background: The role of elevated coagulation factors VIII (FVIII), FIX, FXI for the prediction of recurrent thrombotic events in children after an index non-central venous catheter (non-CVC) related deep vein thrombosis (DVT) remains unclear.
Objective: This study investigates the predictive role of FVIII, FIX, and FXI for recurrent thrombosis in children with index non-CVC DVTs, and the mediation effect of FVIII on chronic inflammation and recurrent thrombosis.
Methods: Children aged 0-18 years diagnosed with an index non-CVC related DVT (1993-2020) were included in this single-center retrospective cohort study.