Publications by authors named "Yushi Niimi"
Bioorg Med Chem
August 2024
Article Synopsis
- NRTIs are drugs used to target HIV reverse transcriptase, but those without a 3'-hydroxy group can lead to drug resistance due to frequent HIV mutations.
- A new NRTI with a 2'-β-methylselenyl modification was developed, which inhibits DNA elongation by HIV-1 RT while maintaining a 3'-hydroxy group.
- This new analog maintains a stable C3'-endo conformation that prevents it from being excised by HIV RT, showing effectiveness against both regular and multidrug-resistant HIV strains.
