* The research introduces an oncolytic virus (VV-ΔTK-4L) designed to enhance immune response in the tumor microenvironment without causing liver damage, leading to longer survival in mice with pancreatic tumors.
* By increasing key immune cell populations and converting the tumor microenvironment from "cold" to "hot," combining VV-ΔTK-4L with PD-1/PD-L1 blockade significantly improves survival rates in mouse models of pancreatic cancer, showing promise for new therapeutic strategies.