Concrete-Inspired Bionic Bone Glue Repairs Osteoporotic Bone Defects by Gluing and Remodeling Aging Macrophages.

Osteoporotic fractures are characterized by abnormal inflammation, deterioration of the bone microenvironment, weakened mechanical properties, and difficulties in osteogenic differentiation. The chronic inflammatory state characterized by aging macrophages leads to delayed or non-healing of the fracture or even the formation of bone defects. The current bottleneck in clinical treatment is to achieve strong fixation of the comminuted bone fragments and effective regulation of the complex microenvironment of aging macrophages.

A microenvironment responsive polyetheretherketone implant with antibacterial and osteoimmunomodulatory properties facilitates osseointegration.

Failure of intraosseous prostheses is primarily attributed to implant loosening and infections. Current primary therapeutic modalities, such as antibiotics and local debridement, not only face challenges in thoroughly eliminating obstinate adhered bacteria but also encounter difficulties in ameliorating undue inflammatory reactions and regenerating impaired peri-implant bone tissues. Polyetheretherketone (PEEK) has excellent mechanical and physicochemical characteristics and has been used extensively as a medical biomaterial.

4f-Orbital mixing increases the magnetic susceptibility of Cp'Eu.

Traditional models of lanthanide electronic structure suggest that bonding is predominantly ionic, and that covalent orbital mixing is not an important factor in determining magnetic properties. Here, 4f orbital mixing and its impact on the magnetic susceptibility of Cp'Eu (Cp' = CHSiMe) was analyzed experimentally using magnetometry and X-ray absorption spectroscopy (XAS) methods at the C K-, Eu M-, and L-edges. Pre-edge features in the experimental and TDDFT-calculated C K-edge XAS spectra provided unequivocal evidence of C 2p and Eu 4f orbital mixing in the π-antibonding orbital of a' symmetry.

Arachidonic acid in aging: New roles for old players.

Background: Arachidonic acid (AA), one of the most ubiquitous polyunsaturated fatty acids (PUFAs), provides fluidity to mammalian cell membranes. It is derived from linoleic acid (LA) and can be transformed into various bioactive metabolites, including prostaglandins (PGs), thromboxanes (TXs), lipoxins (LXs), hydroxy-eicosatetraenoic acids (HETEs), leukotrienes (LTs), and epoxyeicosatrienoic acids (EETs), by different pathways. All these processes are involved in AA metabolism.

Correction: Ferromagnetic and half-metallic phase transition by doping in a one-dimensional narrow-bandgap WPCl semiconductor.

Correction for 'Ferromagnetic and half-metallic phase transition by doping in a one-dimensional narrow-bandgap WPCl semiconductor' by Yusen Qiao , , 2023, , 9835-9842, https://doi.org/10.1039/D3NR01717F.

Spatiotemporal Immunomodulation and Biphasic Osteo-Vascular Aligned Electrospun Membrane for Diabetic Periosteum Regeneration.

Under diabetic conditions, blood glucose fluctuations and exacerbated immunopathological inflammatory environments pose significant challenges to periosteal regenerative repair strategies. Responsive immune regulation in damaged tissues is critical for the immune microenvironment, osteogenesis, and angiogenesis stabilization. Considering the high-glucose microenvironment of such acute injury sites, a functional glucose-responsive immunomodulation-assisted periosteal regeneration composite material-PLA（Polylactic Acid）/COLI(Collagen I）/Lipo(Liposome）-APY29 (PCLA)-is constructed.

Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets.

Inflammatory arthritis, primarily including rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, is a group of chronic inflammatory diseases, whose general feature is joint dysfunction with chronic pain and eventually causes disability in older people. To date, both Western medicine and traditional Chinese medicine (TCM) have developed a variety of therapeutic methods for inflammatory arthritis and achieved excellent results. But there is still a long way to totally cure these diseases.

Ferromagnetic and half-metallic phase transition by doping in a one-dimensional narrow-bandgap WPCl semiconductor.

Based on first-principles calculations, we predict a one-dimensional (1D) semiconductor with cluster-type structure, namely phosphorus-centered tungsten chloride WPCl. The corresponding single-chain system can be prepared from its bulk counterpart by an exfoliation method and it exhibits good thermal and dynamical stability. 1D single-chain WPCl is a narrow direct semiconductor with a bandgap of 0.

An Update on Adipose-Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity.

Over the last decade, adipose-derived stem cells (ADSCs) have attracted increasing attention in the field of regenerative medicine. ADSCs appear to be the most advantageous cell type for regenerative therapies owing to their easy accessibility, multipotency, and active paracrine activity. This review highlights current challenges in translating ADSC-based therapies into clinical settings and discusses novel strategies to overcome the limitations of ADSCs.

Chemokine Regulation in Temporomandibular Joint Disease: A Comprehensive Review.

Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of mastication and joints that connect the mandible to the base of the skull. Although TMJ disorders are associated with symptoms, the causes are not well proven. Chemokines play an important role in the pathogenesis of TMJ disease by promoting chemotaxis inflammatory cells to destroy the joint synovium, cartilage, subchondral bone, and other structures.

WPCl monolayer: an unexplored 2D material with moderate direct bandgap and strong visible-light absorption for highly efficient solar cells.

The discovery of novel two-dimensional (2D) materials with excellent electronic and optoelectronic properties have attracted much scientific attention. Based on the first-principles calculations, we predict an unexplored 2D WPCl monolayer, which is potentially strippable from its bulk counterpart with the exfoliation energy of only 0.16 J m.

High electron mobility and wide-bandgap properties in a novel 1D PdGeS nanochain.

As a versatile platform, one-dimensional (1D) electronic systems host plenty of excellent merits, such as high length-to-diameter ratios, flexible mechanical properties, and manageable electronic characteristics, which endow them with significant potential applications in catalysts, flexible wearable devices, and multifunctional integrated circuits. Herein, based on first-principles calculations, we propose a versatile 1D PdGeS nanochain system. Our calculations show that the 1D PdGeS nanochain can be synthesized simply from its bulk crystal by exfoliation methods and can stably exist at room temperature.

A novel approach to establishing a temporomandibular joint fibrocartilage cell line.

Background/purpose: The temporomandibular joint (TMJ) is a bi-arthrodial joint that is composed of the temporal bone glenoid fossa and the condylar head of the mandible both having fibrocartilaginous articular surfaces. Functional overloading of the TMJ is the main cause of TMJ osteoarthritis (TMJ OA) disease. The aim of this study was to establish immortalized TMJ fibrocartilage cell clones to provide enough cells to adequately investigate the molecular mechanisms studies of TMJ OA.

Electronic structure studies reveal 4f/5d mixing and its effect on bonding characteristics in Ce-imido and -oxo complexes.

This study presents the role of 5d orbitals in the bonding, and electronic and magnetic structure of Ce imido and oxo complexes synthesized with a tris(hydroxylaminato) [((2- BuNO)CHCH)N] (TriNO ) ligand framework, including the reported synthesis and characterization of two new alkali metal-capped Ce oxo species. X-ray spectroscopy measurements reveal that the imido and oxo materials exhibit an intermediate valent ground state of the Ce, displaying hallmark features in the Ce L absorption of partial f-orbital occupancy that are relatively constant for all measured compounds. These spectra feature a double peak consistent with other formal Ce(iv) compounds.

Involvement of 5f Orbitals in the Covalent Bonding between the Uranyl Ion and Trialkyl Phosphine Oxide: Unraveled by Oxygen K-Edge X-ray Absorption Spectroscopy and Density Functional Theory.

Monodentate organophosphorus ligands have been used for the extraction of the uranyl ion (UO) for over half a century and have exhibited exceptional extractability and selectivity toward the uranyl ion due to the presence of the phosphoryl group (O═P). Tributyl phosphate (TBP) is the extractant of the world-renowned PUREX process, which selectively recovers uranium from spent nuclear fuel. Trialkyl phosphine oxide (TRPO) shows extractability toward the uranyl ion that far exceeds that for other metal ions, and it has been used in the TRPO process.

Correction: Enhanced 5f-δ bonding in [U(CH)]: C K-edge XAS, magnetism, and calculations.

Correction for 'Enhanced 5f-δ bonding in [U(CH)]: C K-edge XAS, magnetism, and calculations' by Yusen Qiao , , 2021, , 9562-9565, DOI: 10.1039/D1CC03414F.

Using Redox-Active Ligands to Generate Actinide Ligand Radical Species.

Using a redox-active dioxophenoxazine ligand, DOPO (DOPO = 2,4,6,8-tetra--butyl-1-oxo-1-phenoxazine-9-olate), a family of actinide (U, Th, Np, and Pu) and Hf tris(ligand) coordination compounds was synthesized. The full characterization of these species using H NMR spectroscopy, electronic absorption spectroscopy, SQUID magnetometry, and X-ray crystallography showed that these compounds are analogous and exist in the form M(DOPO)(DOPO), where two ligands are of the oxidized quinone form (DOPO) and the third is of the reduced semiquinone (DOPO) form. The electronic structures of these complexes were further investigated using CASSCF calculations, which revealed electronic structures consistent with metals in the +4 formal oxidation state and one unpaired electron localized on one ligand in each complex.

Enhanced 5f-δ bonding in [U(CH)]: C K-edge XAS, magnetism, and calculations.

5f covalency in [U(CH)] was probed with carbon K-edge X-ray absorption spectroscopy (XAS) and electronic structure theory. The results revealed U 5f orbital participation in δ-bonding in both the ground- and core-excited states; additional 5f ϕ-mixing is observed in the core-excited states. Comparisons with U(CH) show greater δ-covalency for [U(CH)].

Cerium(iv) complexes with guanidinate ligands: intense colors and anomalous electronic structures.

A series of cerium(iv) mixed-ligand guanidinate-amide complexes, {[(MeSi)NC(N Pr)] Ce[N(SiMe)] } ( = 0-3), was prepared by chemical oxidation of the corresponding cerium(iii) complexes, where = 1 and 2 represent novel complexes. The Ce(iv) complexes exhibited a range of intense colors, including red, black, cyan, and green. Notably, increasing the number of the guanidinate ligands from zero to three resulted in significant redshift of the absorption bands from 503 nm (2.

Photocatalytic C-H activation and the subtle role of chlorine radical complexation in reactivity.

The functionalization of methane, ethane, and other alkanes derived from fossil fuels is a central goal in the chemical enterprise. Recently, a photocatalytic system comprising [CeCl(OR)] [Ce, cerium(IV); OR, -OCH or -OCClCH] was disclosed. The system was reportedly capable of alkane activation by alkoxy radicals (RO•) formed by Ce-OR bond photolysis.

Amidinate Supporting Ligands Influence Molecularity in Formation of Uranium Nitrides.

Uranium nitride complexes are attractive targets for chemists as molecular models for the bonding, reactivity, and magnetic properties of next-generation nuclear fuels, but these molecules are uncommon and can be difficult to isolate due to their high reactivity. Here, we describe the synthesis of three new multinuclear uranium nitride complexes, [U(BCMA)](μ-N)(μ-κ:κ-BCMA) (), [(U(BIMA))(μ-N)(μ-NPr)(K(μ-η:η-CHCHNPr)] (), and [U(BIMA)](μ-N)(μ-κ:κ-BIMA) () (BCMA = ,-bis(cyclohexyl)methylamidinate, BIMA = ,-bis(-propyl)methylamidinate), from U(III) and U(IV) amidinate precursors. By varying the amidinate ligand substituents and azide source, we were able to influence the composition and size of these nitride complexes.

Experimental Determination of Magnetic Anisotropy in Exchange-Bias Dysprosium Metallocene Single-Molecule Magnets.

We investigate a family of dinuclear dysprosium metallocene single-molecule magnets (SMMs) bridged by methyl and halogen groups [Cp' Dy(μ-X)] (Cp'=cyclopentadienyltrimethylsilane anion; 1: X=CH ; 2: X=Cl ; 3: X=Br ; 4: X=I ). For the first time, the magnetic easy axes of dysprosium metallocene SMMs are experimentally determined, confirming that the orientation of them are perpendicular to the equatorial plane which is made up of dysprosium and bridging atoms. The orientation of the magnetic easy axis for 1 deviates from the normal direction (by 10.

Structural properties of ultra-small thorium and uranium dioxide nanoparticles embedded in a covalent organic framework.

We report the structural properties of ultra-small ThO and UO nanoparticles (NPs), which were synthesized without strong binding surface ligands by employing a covalent organic framework (COF-5) as an inert template. The resultant NPs were used to observe how structural properties are affected by decreasing grain size within bulk actinide oxides, which has implications for understanding the behavior of nuclear fuel materials. Through a comprehensive characterization strategy, we gain insight regarding how structure at the NP surface differs from the interior.

The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway.

BACKGROUND Osteosarcoma is the most common primary tumor of bone. Interleukin-33 (IL-33) is a pro-inflammatory cytokine that also participates in tumor progression. This study aimed to investigate the role of IL-33 in human osteosarcoma cell viability, proliferation, apoptosis, and epithelial-mesenchymal transition (EMT) in vitro and the molecular mechanisms involved.

CHIP regulates skeletal development and postnatal bone growth.

C terminus of Hsc70-interacting protein (CHIP) is a chaperone-dependent and U-box containing E3 ubiquitin ligase. In previous studies, we found that CHIP regulates the stability of multiple tumor necrosis factor receptor-associated factor proteins in bone cells. In Chip global knockout (KO) mice, nuclear factor-κB signaling is activated, osteoclast formation is increased, osteoblast differentiation is inhibited, and bone mass is decreased in postnatal Chip KO mice.