Publications by authors named "Yusei Sato"
Cellular aging causes declining cell functionality, gradually disrupting cellular homeostasis. Mitochondria are crucial in numerous metabolic processes, including the electron transport chain and fatty acid β-oxidation. Mitochondrial dysfunction is closely linked to aging-related liver dysfunction because it impairs fatty acid metabolism, potentially leading to nonalcoholic fatty liver disease.
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- This study explored the impact of nutritional guidance centered on leucine intake versus general nutritional advice on cardiac rehabilitation patients regarding plasma leucine levels, lean body mass, and muscle strength.
- After six months, only the intervention group had significant increases in protein and leucine intake, and there was a noticeable rise in lean body mass compared to the control group.
- The results suggest that enhanced leucine concentration through targeted nutritional guidance can positively affect lean body mass and grip strength in patients, without requiring more intensive training.
Myosin-induced F-actin fragmentation facilitates contraction of actin networks.
Cytoskeleton (Hoboken)
August 2024
Article Synopsis
- Mechanical forces are essential for various biological processes like cell movement and division, largely driven by the interaction between actin filaments and myosin motors in the actin cytoskeleton.
- Recent research highlights the importance of two key factors in actin network contraction: F-actin buckling caused by motor activities and the tension-induced fragmentation of F-actins, which disrupts network integrity.
- This study used experiments and computational models to reveal that tension-induced fragmentation not only contributes to network contraction but also creates different rupture dynamics compared to other mechanisms, emphasizing its significance in highly interconnected actomyosin networks.
Effect of temperature on actin filament corkscrewing driven by nonprocessive myosin IC.
Biochem Biophys Res Commun
April 2024
Article Synopsis
- - Myosin family proteins are motor proteins that use ATP to generate force along actin filaments, and this study focuses on how temperature affects their corkscrewing motion.
- - The research involved in vitro assays with a specific myosin (Drosophila myosin IC) and found that increasing temperature (from 25°C to 35°C) leads to higher gliding and rotational velocities of actin filaments.
- - Results show that at warmer temperatures, the gliding velocity increases more than the rotational velocity, suggesting temperature influences how myosin IC generates torque on actin filaments, which could be important for understanding muscle function at physiological temperatures.
Article Synopsis
- * This study tracked the movement of actin filaments using quantum dots to show that myosin IC can cause the filaments to rotate as they glide across a surface coated with myosin IC.
- * The research found that the degree of rotation is influenced by the concentration of a specific phospholipid (PI[4,5]P) in the membrane, suggesting that the mechanical actions of myosin IC can be adjusted depending on the lipid environment.
Article Synopsis
- Young adults with dilated cardiomyopathy (DCM) experience significant health-related quality of life (HR-QOL) issues due to their condition and typical life stressors, such as career and relationship building.
- A case study of a 26-year-old man in a cardiac rehabilitation program showed improved exercise capacity and some HR-QOL improvements, but many emotional and social factors remained unchanged.
- The importance of addressing both physical and psychosocial aspects in young patients with DCM was emphasized, highlighting the need for comprehensive care that includes counseling and support during rehabilitation.
Background: Malnutrition impairs quality of life and prognosis of patients with cardiovascular disease. The Mini Nutritional Assessment (MNA) is a screening tool developed for the nutritional assessment of older adults. However, usefulness of MNA for patients undergoing cardiac rehabilitation (CR) has not been fully investigated.
View Article and Find Full Text PDFBackground: PixeeMo™ is a compact instrument that enables bacterial cell counting using microfluidic chips instead of counting of colonies on culture media. Chips containing electrodes, based on fluid, electric filtering and sorting technology (FES), allow the selection of bacterial cells from other components in the sample. In the United States (US), surface water or ground water affected by surface water must be treated to reduce the total microbial load to less than 500 CFU/mL.
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