Dynamic Peptide Nanoframework-Guided Protein Coassembly: Advancing Adhesion Performance with Hierarchical Structures.

Hierarchical structures are essential in natural adhesion systems. Replicating these in synthetic adhesives is challenging due to intricate molecular mechanisms and multiscale processes. Here, we report three phosphorylated peptides featuring a hydrophobic self-assembly motif linked to a hydrophilic phosphorylated sequence (pSGSS), forming peptide fibril nanoframeworks.

A Hydroxylamine-Mediated Amidination of Lysine Residues That Retains the Protein's Positive Charge.

Lysine-specific peptide and protein modification strategies are widely used to study charge-related functions and applications. However, these strategies often result in the loss of the positive charge on lysine, significantly impacting the charge-related properties of proteins. Herein, we report a strategy to preserve the positive charge and selectively convert amines in lysine side chains to amidines using nitriles and hydroxylamine under aqueous conditions.

Biomimetic Mineralization: From Microscopic to Macroscopic Materials and Their Biomedical Applications.

Biomineralization is an attractive pathway to produce mineral-based biomaterials with high performance and hierarchical structures. To date, the biomineralization process and mechanism have been extensively studied, especially for the formation of bone, teeth, and nacre. Inspired by those, abundant biomimetic mineralized materials have been fabricated for biomedical applications.

Exploring the generality of ligands for Silica-Encapsulated nanoclusters as SERS labels.

The surface enhanced Raman scattering (SERS) reporters are rather limited, and the Raman peaks still overlap in varying degrees, making SERS multiplex coding a critical bottleneck in the exploration of SERS nanotechnology. Herein, we design a general strategy to expand the SERS probe scope to 26 probes of six types, which can be further expanded within a limited range, with stable performance and structure. By constructing (Au-aggregate)@Ag@silica and (Au-aggregate)@silica nanocomposites, we develop optimal enhancement strategies for each Raman molecules.

Engineering DNA-Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications.

Programmable base pair interactions at the nanoscale make DNA an attractive scaffold for forming hydroxyapatite (HAP) nanostructures. However, engineering macroscale HAP mineralization guided by DNA molecules remains challenging. To overcome this issue, a facile strategy is developed for the fabrication of ultrastiff DNA-HAP bulk composites.

Designing caps for colloidal Au nanoparticles.

The plasmonic property of a nanostructure is highly dependent on its morphology, but there are few methods for appending a domain as the "functional group" or modifier. As a means of modulating plasmonic properties, we create and modulate Au hats on Au nanoparticles, including mortarboards, beret hats, helmets, crowns, antler hats and antenna hats. The structural control arises from the active surface growth as a result of dynamic competition between ligand absorption and metal deposition.

Multiplexed SERS Barcodes for Anti-Counterfeiting.

Forged signature threatens the authenticity of personal identity. Here, an effective SERS anti-counterfeiting system is designed for personal signatures. Mixed ligands improve the complexity of Raman spectra and expand the coding capacity.

Self-Healing of Polarizing Films via the Synergy between Gold Nanorods and Vitrimer.

Conventional self-healing is about the recovery of shape and mechanical properties. In contrast, recovery of functional properties is still a great challenge, especially for optical functional materials, as the known self-healing methods are incompatible with optical properties. By utilizing the synergistic effect between Au nanorods and vitrimer, the alignment of Au nanorods can be achieved in the crosslinked polymer.