Cell functioning in norm and pathology in terms of the activity paradigm: Oncogenesis.

Over the past years many theories of carcinogenesis have been developed. Nowadays, there are two prevalent theories of carcinogenesis - two-hit hypothesis, which considers mutations as the main factor in malignization and tissue hypothesis, which considers tissue homeostasis disruption for providing cells transformation. Both of these theories explain cancer origin basing on principles of the reactivity paradigm.