Publications by authors named "Yurou Wu"

It is widely acknowledged that we are currently facing a critical tipping point with regards to global extinction, with human activities driving us perilously close to the brink of a devastating sixth mass extinction. As a promising option for safeguarding endangered species, induced pluripotent stem cells (iPSCs) hold great potential to aid in the preservation of threatened animal populations. For endangered species, such as the northern white rhinoceros (Ceratotherium simum cottoni), supply of embryos is often limited.

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Ethnopharmacological Relevance: Saiga antelope horn (SAH) is derived from the Saiga antelope (Saiga tatarica Linnaeus) of the bovidae family. SAH has been used for the treatment of febrile seizures (FS) in children for thousands of years in China. Due to the biological protection of Saiga antelope and its ethical reasons, the application of SAH has been widely restricted.

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In recent years, great breakthroughs have been made in basic research and clinical applications of stem cells in regenerative medicine and other fields, which continue to inspire people to explore the field of stem cells. With nearly unlimited self-renewal ability, stem cells can generate at least one type of highly differentiated daughter cell, which provides broad development prospects for the treatment of human organ damage and other diseases. In the field of stem cell research, related technologies for inducing or isolating stem cells are relatively mature, and a variety of stable stem cell lines have been successfully constructed.

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The discovery of new therapeutic drugs is heavily reliant on the structural diversity and pharmacological properties of heterocyclic compounds. Pyridine heterocyclic-related medicines, in particular, have garnered considerable attention due to their wide pharmacological activities and therapeutic effects. Among them, cyanopyridine derivatives have demonstrated diverse pharmacological effects.

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Cell penetrating peptide derived from human eosinophil cationic protein (CPPecp) is a 10-amino-acid peptide containing a core heparan sulfate (HS)-binding motif of human eosinophil cationic protein (ECP). It binds and penetrates bronchial epithelial cells without cytotoxic effects. Here we investigated airway-protective effects of CPPecp in BEAS-2B cell line and mite-induced airway allergic inflammation in BALB/c mice.

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Article Synopsis
  • The study investigated the impact of different molecular weights of inhaled heparins on T helper cell differentiation in a mite allergy model using BALB/c mice.
  • Mice were divided into four groups: a control group, a mite sensitized group, and two heparin-treated groups (regular and low molecular weight), with various tests conducted to analyze immune responses.
  • Results showed that both heparin treatments significantly reduced serum IgE levels and decreased the expression of key immune markers in the spleen compared to the mite sensitized group, suggesting potential therapeutic effects worth exploring further.
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