Blood reflux and metabolic regulation play important roles in chronic venous disease (CVD) development. Histone deacetylases (HDACs) and DNA methyltransferases (DNMTs) serve as repressors that inhibit metabolic signaling, which is induced by proatherogenic flow to promote aortic endothelial cell (EC) dysfunction and atherosclerosis. The aim of this study was to elucidate the relationship between blood reflux and epigenetic factors HDACs and DNMTs in CVD.
View Article and Find Full Text PDFUsing first-principles calculations based on density functional theory, we systematically investigated the electronic properties and charge transfer of topological insulator BiTeSe thin films under an external electric field. As the selenium content in BiTeSe thin films increases, the band gap is gradually opened, with changes in the charge distribution. In addition, the experimentally stable BiTeSe and BiSeTe thin films are extremely robust under vertical electric fields up to 0.
View Article and Find Full Text PDFJ Phys Condens Matter
September 2019
Magnetic doping in topological insulator SbTe can produce very novel physical phenomena such as quantum anomalous Hall effect (QAHE). However, experimental observations of QAHE in the magnetic atoms doped SbTe have encountered significant challenges due to the complexity of the electronic structure and the relatively small band gap. Generally, mechanical strain can effectively modulate the band structure, thus we theoretically investigate the electronic structures of Cr-doped SbTe under mechanical strain using first-principles calculations within density functional theory.
View Article and Find Full Text PDFGeSe is considered as a potential absorber material for thin film solar cells owing to its ideal band gap, strong light absorption, remarkable air durability, Earth-abundance and non-toxic constituents. However, the high vapor pressure of GeSe at a temperature below its melting point makes it difficult to synthesize a high-quality GeSe film. To alleviate this limitation, in this work, a thermal evaporation combining a novel sandwiching post-annealing method was introduced to deposit high quality GeSe thin films with (100)-orientation.
View Article and Find Full Text PDFHeteroatom-doping is a promising strategy to tuning the microstructure of carbon material toward improved electrochemical storage performance. However, it is a big challenge to control the doping sites for heteroatom-doping and the rational design of doping is urgently needed. Herein, S doping sites and the influence of interlayer spacing for two kinds of hard carbon, perfect structure and vacancy defect structure, are explored by the first-principles method.
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