Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy.

RNA degradation using ribonuclease targeting chimeras (RiboTACs) is a promising approach for cancer therapy. However, potential off-target degradation is a serious issue. Here, a RiboTAC is designed for tumor microenvironment triggered activation.

regulates gut microbiota and ameliorates the alcoholic-associated liver disease in mice.

Introduction: Alcoholic-associated liver diseases (ALD) are now widespread issues worldwide. Alcoholic-induced chronic dysbiosis of the gut microbiota is one of the factors in the pathophysiology of ALD.

Methods: In this work, we employed a chronic-binge ethanol feeding mice model, as described in a previous report.

Postbiotics from promote intestinal health performance through regulation of in weaned piglets.

Postbiotics are attractive as alternatives to antibiotics for use against post-weaning diarrhea. However, their beneficial mechanisms are largely unknown. In the current study, we first demonstrated that supplementation with 0.

Effects of Noise Exposure and Mental Workload on Physiological Responses during Task Execution.

Twelve healthy male students were recruited to investigate the physiological response to different noise exposure and mental workload (MW) conditions, while performing multi-attribute task battery (MATB) tasks. The experiments were conducted under three noise exposure conditions, with different sound pressure levels and sharpness. After adaptation to each noise condition, the participants were required to perform the resting test and the MATB task tests with low, medium, and high MW.

Bacillus coagulans in Combination with Chitooligosaccharides Regulates Gut Microbiota and Ameliorates the DSS-Induced Colitis in Mice.

Ulcerative colitis (UC) are chronic inflammatory disorders, which may be caused by intestinal barrier dysfunction, immune system disorders and intestinal microbiota dysbiosis. Synbiotic, the combination of probiotics and prebiotics, is thought to be a pragmatic approach in mitigating inflammation in UC. Bacillus coagulans has been recognized as a potential probiotic for treating intestinal diseases because of its favorable industrial and probiotic properties, including sporulation and lactic acid production.