Glioblastoma (GBM) is a lethal brain cancer known for its rapid invasion of brain tissue, making it essential to find ways to slow its progression.
Researchers developed an embryo-larval zebrafish xenograft model to study how GBM cells grow and spread in a naturally dynamic brain environment.
The study revealed that the extracellular matrix protein laminin alpha 5 (lama5) reduces GBM cell dispersal and invasion, while promoting the formation of blood vessel-dependent microtumors, indicating its complex role in GBM behavior.