Publications by authors named "Yuriy Gubenko"

Objective: Medicolegal examination of an intervention as common as endotracheal intubation may be valuable to physicians in many specialties. Our objectives were to comprehensively detail the factors raised in litigation to better educate physicians on strategies for minimizing liability and augmenting patient safety.

Methods: Publicly available court records were searched for pertinent litigation.

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Background: Transesophageal echocardiography can be a useful monitor during noncardiac surgery, in patients with comorbidities and/or undergoing procedures associated with substantial hemodynamic changes. The goal of this study was to investigate if transesophageal-echocardiography-related knowledge could be acquired during anesthesia residency.

Methods: After institutional review board approval, a prospective observational study was performed in two anesthesiology residency programs.

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Importance: Prolonged anesthesia and operative times have deleterious effects on surgical outcomes in a variety of procedures. However, data regarding the influence of anesthesia duration on microvascular reconstruction of the head and neck are lacking.

Objective: To examine the association of anesthesia duration with complications after microvascular reconstruction of the head and neck.

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Orthotopic liver transplant (OLT) remains the standard of care for end stage liver disease. To circumvent allo-rejection, OLT subjects receive gluococorticoids (GC). We investigated the effects of GC on endogenous mesenchymal stem (stromal) cells (MSCs) in OLT.

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Background: Expert witnesses serve a crucial role in the medicolegal system, interpreting evidence so that it can be understood by jurors. Guidelines have been established by both the legal community and professional medical societies detailing the expectations of expert witnesses. The primary objective of this analysis was to evaluate the expertise of anesthesiologists testifying as expert witnesses in malpractice litigation.

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Article Synopsis
  • The blood-brain barrier (BBB) makes it challenging to deliver drugs effectively for brain cancers and neurodegenerative diseases.
  • Stem cells, particularly neural stem cells (NSCs) and mesenchymal stem cells (MSCs), offer potential as delivery vehicles since they can cross the BBB and target brain tumors like glioblastoma multiforme (GBM).
  • MSCs are considered a safer option than embryonic stem cells, as they do not form tumors and can migrate to areas of injury, making them suitable for clinical trials and potentially available for quick use in treatments.
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Objective: To determine whether sevoflurane, because of its lower blood/gas partition coefficient, compared with isoflurane as the primary anesthetic agent, allows earlier tracheal extubation and assessment of cognitive function after off-pump coronary artery bypass (OPCAB) surgery.

Design: Prospectively, patients were randomly assigned to receive sevoflurane or isoflurane as their primary anesthetic. Intraoperative opioids were limited to 5 microg/kg of fentanyl.

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During orthotopic liver transplantation a patient received epsilon-aminocaproic acid and clotting factors. Shortly after hepatic artery clamping the patient developed a massive intracardiac/intravascular thrombosis that resulted in cardiac arrest. After diagnosis by transesophageal echocardiography, the patient was treated with recombinant tissue plasminogen activator through a central venous catheter advanced into the right atrium.

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