C fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue.

Background: Bioactive soluble carbon nanostructures, such as the C fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C fullerene aqueous colloid solution (CFAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats.

Catalytic system of the reactive oxygen species on the C60 fullerene basis.

Aim: To study the ability of fullerenes C(60) to catalyse the reactions of generation of reactive oxygen species (ROS) in water solution after photoexcitation and to affect the vitality of tumor cells in vitro.

Methods: The number and vitality of cultured Ehrlich carcinoma cells or rat thymocytes were determined using tripane blue, ROS levels were registered using the methods of electron paramagnetic resonance (EPR) spectroscopy and spin traps, photoirradiation of water solution of fullerenes C(60) with visible light was carried out using mercury lamp.

Results: Irradiation of water solution of fullerenes C(60) (10(-5) M) was accompanied with generation of ROS with the rate of 10 nMol/ml/min.