Publications by authors named "Yuri Yepez"
Aquatic mammals (marine and freshwater species) share significant and similar adaptations, enabling them to tolerate hypoxia during regular breath-hold diving. Despite the established importance of HIF1A, a master regulator in the molecular mechanism of hypoxia response, and other associated genes, their role in the evolutionary adaptation of aquatic mammals is not fully understood. In this study, we investigated this topic by employing a candidate gene approach to analyze 11 critical genes involved in the HIF1A signaling pathway in aquatic mammals.
View Article and Find Full Text PDFOur goal was to describe in more detail the evolutionary history of Gamma and two derived lineages (P.1.1 and P.
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- STAT2 plays a crucial role in the immune response to viral infections, especially following type I interferon release, but many flaviviruses attack and impair STAT2 to weaken this defense.
- A study analyzed the STAT2 coding sequences from 28 rodent species and 49 primate species, finding various sites influenced by positive selection, particularly in relation to susceptibility to flavivirus infections.
- Results indicate that certain positively selected sites in the STAT2 gene contribute to the protein's stability and interaction with a flavivirus protein, suggesting that rodents may have a slight evolutionary edge over primates in defending against these viruses due to faster evolutionary rates.