Publications by authors named "Yuri V Gervaziev"
Article Synopsis
- Stellate genes, located on the X chromosome of Drosophila melanogaster, are essential for male fertility and encode a protein similar to a subunit of protein kinase CK2.
- Over-expression of these genes due to derepression leads to meiotic disruptions and male sterility.
- The study identifies important E-boxes in the Stellate gene promoters that interact with the dUSF protein, highlighting their role in regulating gene expression specifically in the testes.
ECAR-LANS, the recombinant L-asparaginase from Erwinia carotovora, is a prospective therapeutic enzyme for leukaemia treatment. An efficient and economical scheme was developed for the purification, cloning and expression in Eschericha coli of ECAR-LANS. More than 90% purity, complemented with 72% active enzyme recovery, was achieved with a single chromatographic purification step.
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