Prognostic impact of cytokines and chemokines in bronchoalveolar lavage fluid on acute exacerbation of fibrosing interstitial lung disease.

Background And Objective: Acute exacerbation of fibrosing interstitial lung disease (AE-FILD) is a serious condition with a high mortality rate. We aimed to comprehensively analyze cytokines in bronchoalveolar lavage fluid and their association with the clinical course of AE-FILD.

Methods: We retrospectively enrolled 60 patients with AE-FILD who underwent bronchoalveolar lavage.

Longitudinal changes in mental health outcomes after COVID-19 hospitalization: A prospective study.

Background: The long-term trends of COVID-19 mental sequelae remain unknown. Thus, this study aimed to survey the one-year temporal trends of PTSD and health-related quality of life of COVID-19 survivors.

Methods: Patients hospitalized with COVID-19 were followed up at three, six, and 12 months after discharge.

Visualization of orthodontic forces generated by aligner-type appliances.

Recently, the number of patients who request esthetically pleasing aligner-type orthodontic appliances (referred to as aligners) has been increasing. However, the orthodontic forces generated by these aligners are still unknown. This study aimed to verify whether the orthodontic force in aligners can be estimated by measuring near infrared 2D birefringence, and to visualize the orthodontic force.

Gastrointestinal perforation following dabrafenib and trametinib administration in non-small cell lung carcinoma with BRAF V600E mutation: a case report and literature review.

Gastrointestinal perforation related to mitogen-activated protein kinase kinase (MEK) inhibitors has been reported previously; however, there has been no case report of such a condition in patients with non-small cell lung cancer (NSCLC). Herein, we report a case of small intestinal perforation secondary to dabrafenib and trametinib administration, but not related to tumor regression. A 62-year-old man with non-small cell lung cancer harboring BRAF V600E mutation was treated with dabrafenib and trametinib.

Skin regeneration of amphibians: A novel model for skin regeneration as adults.

Adult mammals do not regenerate the dermis of the skin but form a scar after a deep skin injury. Since a scar causes serious medical problems, skin regeneration, instead of formation of a scar, has been strongly desired from a clinical point of view. Recent studies have suggested multiple origins of myofibroblasts, which are scar-forming cells in skin wound healing of mammals.