Publications by authors named "Yuri Ledezma"
Biotechnol Adv
March 2023
Article Synopsis
- CHO cells are essential in the biopharmaceutical industry, prompting extensive use of genetic engineering techniques like CRISPR-Cas to enhance their performance in protein production.
- This review highlights recent advances using various CRISPR-Cas systems to improve recombinant protein output in CHO cells while discussing the benefits, limitations, and challenges of these methods.
- Emphasis is placed on how gene regulation affects glycan composition, influencing the properties of therapeutic proteins, and the future potential of CRISPR technology for developing more efficient CHO cell lines, necessitating further research to unlock its full capabilities.
